| Substance |
Info | Dose |
Warn | Link |
PubMed |
Latest article |
| Curcumin | 📋 | ✍ | ⛔ | | 40531313 | Curcumin inhibits the neuroimmune response mediated by mast cells after pulpitis |
| Aloe Vera | 📋 | ✍ | ⛔ | | 39909775 | Effectiveness of Aloe vera in the treatment of oral mucositis: a systematic review and meta-analysis of randomized controlled trials |
| Bee Propolis | 📋 | ✍ | ⛔ | | 40428017 | Comparative Evaluation of Natural Mouthrinses and Chlorhexidine in Dental Plaque Management: A Pilot Randomized Clinical Trial |
| Melatonin | 📋 | ✍ | ⛔ | | 40277508 | Effects of Vitamin D, Melatonin, and Omega-3 Fatty Acids on Periodontal Health: A Narrative Review |
| Vitamin D3 | 📋 | ✍ | ⛔ | | 40373828 | Increasing Serum Vitamin D Levels Reduces Gingival Crevicular Fluid Matrix Metalloproteinase-9 Levels in Periodontal Health and Diseases |
| Resveratrol | 📋 | ✍ | ⛔ | | 40272637 | Resveratrol inhibits the progression of oral squamouscell carcinoma through Norad/Igf2bp2/Pdk1 pathway and remodeling glucose metabolism reprogramming |
| Quercetin | 📋 | ✍ | ⛔ | | 40009568 | Activation of SIRT3/AMPK/mTOR-mediated autophagy promotes quercetin-induced ferroptosis in oral squamous cell carcinoma |
| EGCG | 📋 | ✍ | ⛔ | | 40348029 | Epigallocatechin gallate with nobiletin as a novel combination therapy to induce autophagy and apoptosis in oral cancer |
| Vitamin C | 📋 | ✍ | ⛔ | | 39886720 | Evaluation of the Effect of Topically Applied Melatonin and Vitamin C in the Non-surgical Treatment of Chronic Periodontitis: A Triple-Blind Randomized Clinical Trial |
| Omega-3 Fatty Acids | 📋 | ✍ | ⛔ | | 40277508 | Effects of Vitamin D, Melatonin, and Omega-3 Fatty Acids on Periodontal Health: A Narrative Review |
| Probiotics | 📋 | ✍ | ⛔ | | 40199865 | Probiotics and prebiotics: new treatment strategies for oral potentially malignant disorders and gastrointestinal precancerous lesions |
| Cannabidiol | 📋 | ✍ | ⛔ | | 40565932 | Cannabidiol for Orofacial and Upper-Quarter Pain: A Systematic Evaluation of Therapeutic Potential |
| Lycopene | 📋 | ✍ | ⛔ | | 40445467 | Lycopene: a promising adjuvant to photodynamic therapy in oral cancer |
| Licorice Root | 📋 | ✍ | ⛔ | | 39687825 | Evaluation of the Antimicrobial Efficacy of Ethanolic and Aqueous Extracts of Licorice (Glycyrrhiza glabra) Against a Periodontal Pathogen: An In Vitro Study |
| Holy Basil | 📋 | ✍ | ⛔ | | 40061696 | In Silico Molecular Docking of Ocimum sanctum Phytochemicals: Targeting Key Biomarkers in Oral Cancer |
| Grape Seed extract | 📋 | ✍ | ⛔ | | 38833771 | Dietary supplementation with grape seed extract from Vitus vinifera prevents suppression of GABAergic protein expression in female Sprague Dawley trigeminal ganglion in a model of chronic temporomandibular joint disorder |
| Medicinal Plants | 📋 | | | | 40097871 | From cell lines to animal models: "plant- derived chemotherapeutics unlocking new frontiers against oral squamous cell carcinoma"-a comprehensive systematic review |
| Chamomile | 📋 | ✍ | ⛔ | | 39595193 | Chamomile Tincture and Lidocaine Hydrochloride Gel Ameliorates Periodontitis: A Preclinical Study |
| Green Tea | 📋 | ✍ | ⛔ | | 40143184 | Green Tea: A Novel Perspective on the Traditional Plant's Potential in Managing Periodontal Diseases |
| Green Tea Polyphenols | 📋 | ✍ | ⛔ | | 40546664 | Evaluation of the clinical efficacy of green tea extract gel as local drug delivery for periodontitis |
| Micronutrients | 📋 | | ⛔ | | 40114212 | Association between adjustable dietary factors and periodontitis: NHANES 2009-2014 and Mendelian randomization |
| Pomegranate Peel extract | 📋 | ✍ | ⛔ | | 39857388 | Anti-Inflammatory, Antioxidant and Antibacterial Properties of Tomato Skin and Pomegranate Peel Extracts: A Sustainable Approach for Oral Health Care |
| Ginsenosides | 📋 | ✍ | ⛔ | | 40207166 | The inhibitory effects of ginsenosides on periodontitis pathogenic bacteria |
| Pomegranate | 📋 | | ⛔ | | 40496699 | Effects of pomegranate extract on preventing dental caries: a systematic review |
| Honey | 📋 | ✍ | ⛔ | | 38710295 | Efficacy of Natural Products in Preventing Oral Mucositis Resulting from Cancer Therapies: A Network Meta-analysis of Randomized Controlled Trials |
| Turmeric | 📋 | ✍ | ⛔ | | 39502958 | Comparative Analysis of Turmeric and Chlorhexidine Mouthwashes as Anti-plaque and Anti-gingivitis Agents: An Observational Study |
| Neem | 📋 | ✍ | | | 39554682 | Clinical efficacy of Azadirachta indica based herbal mouthwash in treating the hypersensitivity of teeth |
| Vitamin E | 📋 | ✍ | ⛔ | | 39992015 | The Association of Intake of Vitamin Mixtures With Periodontitis: A Machine Learning Approach on NHANES |
| Berberine | 📋 | ✍ | ⛔ | | 40339228 | Berberine promotes apoptosis and inhibits the migration of oral squamous carcinoma cells through inhibition of the RAGE/PI3K/AKT/mTOR pathway |
| Cinnamaldehyde | 📋 | | | | 37268049 | Cinnamaldehyde inhibits Enterococcus faecalis biofilm formation and promotes clearance of its colonization by modulation of phagocytes in vitro |
| Cranberry | 📋 | ✍ | ⛔ | | 40417439 | Comparative Assessment of Efficacy of Cranberry Extract Mouthwash and Fluoride Mouthwash on Streptococcus mutans Count as an Adjunct to Conventional Caries Management among 6-12-year-old Children: A Randomized Controlled Trial |
| Metformin | 📋 | ✍ | ⛔ | | 39272875 | A Narrative Review: Repurposing Metformin as a Potential Therapeutic Agent for Oral Cancer |
| Essential Oils | 📋 | | ⛔ | | 38310236 | Efficacy of flossing and mouth rinsing regimens on plaque and gingivitis: a randomized clinical trial |
| Tea Tree Essential Oil | 📋 | | ⛔ | | 40277479 | Clinical and Microbiological Evaluation of 0.2% Tea Tree Oil Mouthwash in Prevention of Dental Biofilm-Induced Gingivitis |
| Bromelain | 📋 | ✍ | ⛔ | | 40136760 | Effects of Bromelain and Papain in Tooth Whitening and Caries Removal: A Literature Review |
| N-Acetyl Cysteine | 📋 | ✍ | ⛔ | | 39473642 | Evaluating the Impact of Different Treatments on the Quality of Life in Patients With Burning Mouth Syndrome: A Scoping Review |
| Astaxanthin | 📋 | ✍ | ⛔ | | 39668460 | Astaxanthin Increases Tumor Suppressor Gene Expression and Affects Cellular Biological Behavior in Oral Dysplastic Keratinocytes by Regulating DNA Methylation |
| Baicalein | 📋 | ✍ | ⛔ | | 39180042 | Investigation of the mechanism of baicalein in the treatment of periodontitis based on network pharmacology, molecular docking and experimental validation |
| Coconut Oil | 📋 | | ⛔ | | 39926945 | Comparison and Evaluation of the Efficacy of Sesame Oil, Coconut Oil, and Sunflower Oil Pulling on Gingival Health-A Triple-Blind Randomized Clinical Trial |
| Eugenol | 📋 | | | | 39416730 | In Vitro Anticancer Potential of Eugenol on Oral Cancer Cell Lines: A Systematic Review |
| Moringa Oleifera | 📋 | ✍ | ⛔ | | 39570553 | Anticancer effect of Moringa oleifera in oral squamous cell carcinoma: a systematic review |
| Phytochemicals | 📋 | | | | 40235544 | Natural compounds: new therapeutic approach for inhibition of Streptococcus mutans and dental caries |
| Baicalin | 📋 | ✍ | ⛔ | | 40211339 | Baicalin attenuates LPS-induced periodontal inflammation response by inhibiting autophagy |
| Cinnamon | 📋 | ✍ | ⛔ | | 34447078 | Cariostatic Efficacy of Cinnamon Water Extract on Streptococcus mutans: An In vitro Study |
| Cinnamon Essential Oil | 📋 | ✍ | ⛔ | | 39664834 | Effect of Herbal Extract of Spilanthes acmella and Cinnamon Oil on Enterococcus faecalis Biofilm Eradication: An In Vitro Study |
| Hesperidin | 📋 | ✍ | ⛔ | | 39162858 | Anti-inflammatory effects of hesperidin on human gingival fibroblasts stimulated by lipopolysaccharide of Porphyromonas gingivalis in vitro |
| Hyaluronic Acid | 📋 | ✍ | ⛔ | | 39672374 | The potential anti-inflammatory effect of hyaluronic acid gel alone or in combination with grapefruit seed extract on induced periodontitis in mandibular molars of Wistar rats |
| Nigella Sativa | 📋 | ✍ | ⛔ | | 38744331 | The Anti-Inflammatory Effect of Nigella sativa Toothpaste on Porphyromonas gingivalis Bacteria Through Decreased TNF-α, MMP-9, PGE-2 Expression in Wistar Rats |
| Zinc | 📋 | ✍ | ⛔ | | 36864527 | Prevention of radiotherapy-related oral mucositis with zinc and polyherbal mouthwash: a double-blind, randomized clinical trial |
| Capsaicin | 📋 | ✍ | ⛔ | | 39435241 | Capsaicin Promotes Apoptosis and Inhibits Cell Migration via the Tumor Necrosis Factor-Alpha (TNFα) and Nuclear Factor Kappa B (NFκB) Signaling Pathway in Oral Cancer Cells |
| Carvacrol | 📋 | ✍ | ⛔ | | 39320020 | Carvacrol inhibits the progression of oral submucous fibrosis via downregulation of PVT1/miR-20a-5p-mediated pyroptosis |
| Luteolin | 📋 | ✍ | ⛔ | | 39579538 | Luteolin ameliorates periodontitis by modulating mitochondrial dynamics and macrophage polarization via the JAK2/STAT3 pathway |
| Sesame Oil | 📋 | | ⛔ | | 39926945 | Comparison and Evaluation of the Efficacy of Sesame Oil, Coconut Oil, and Sunflower Oil Pulling on Gingival Health-A Triple-Blind Randomized Clinical Trial |
| Sodium Bicarbonate | 📋 | ✍ | ⛔ | | 40482904 | A randomised, controlled, trial investigating the effect of tooth brushing with a sodium bicarbonate toothpaste for 12 weeks compared to a conventional fluoride toothpaste on gingivitis |
| Andrographolide | 📋 | | | | 39229580 | Andrographolide demonstrates anti-proliferative activity in oral cancer by promoting apoptosis, the programmed cell death process |
| Apigenin | 📋 | ✍ | ⛔ | | 38881938 | Apigenin suppresses the low oxaliplatin-induced epithelial-mesenchymal transition in oral squamous cell carcinoma cells via LINC00857 |
| Frankincense | 📋 | ✍ | ⛔ | | 40202962 | Assessing the efficacy of frankincense extract as a root canal irrigant against Enterococcus faecalis |
| Gotu Kola | 📋 | ✍ | ⛔ | | 40253389 | Efficacy of Centella asiatica on mitigating temporomandibular pain and improving functionality: a randomized, double blind, pilot clinical trial |
| L-Glutamine | 📋 | ✍ | ⛔ | | 40198535 | Glutamine Mouthwash for Preventing Methotrexate-Induced Mucositis in Children with Acute Lymphoblastic Leukemia: A Randomized Cross-Over Trial |
| Licochalcones | 📋 | | | | 32632823 | Biocompatible combinations of nisin and licorice polyphenols exert synergistic bactericidal effects against Enterococcus faecalis and inhibit NF-κB activation in monocytes |
| Lipoic Acid | 📋 | ✍ | ⛔ | | 40092892 | Effect of oral alpha lipoic acid in treatment of OSMF |
| Magnesium | 📋 | ✍ | ⛔ | | 39970359 | The role of magnesium in the prevention and treatment of dental caries - the latest research |
| Magnolol | 📋 | | | | 39187336 | Magnolol's Therapeutic Efficacy and Immunomodulatory Effects in Oral Squamous Cell Carcinoma |
| Mangosteen | 📋 | ✍ | ⛔ | | 38034260 | Inhibition of Oral Fibrinogenesis Through Transforming Growth Factor-Beta/SMAD2/3 Signalling Inhibition Using Mangosteen Pericarp Extract |
| Naringenin | 📋 | ✍ | ⛔ | | 40575446 | An in-vitro exploration of the antifibrotic activity of Naringenin: A potential therapeutic agent for oral submucous fibrosis management |
| Pine Bark | 📋 | ✍ | ⛔ | | 40362854 | Impact of a Dietary Supplementation with French Maritime Pine Bark Extract Pycnogenol® on Salivary and Serum Inflammatory Biomarkers During Non-Surgical Periodontal Therapy-A Randomized Placebo-Controlled Double-Blind Trial |
| Thymoquinone | 📋 | | ⛔ | | 39337239 | An Assessment of the Clinical Efficacy of a Topical Application of 5% Thymoquinone Gel for Plaque-Induced Gingivitis Patients: A Randomized Controlled Clinical Trial |
| Vitamin A | 📋 | ✍ | ⛔ | | 39992015 | The Association of Intake of Vitamin Mixtures With Periodontitis: A Machine Learning Approach on NHANES |
| Aged Garlic | 📋 | ✍ | ⛔ | | 40297801 | Effects of aged garlic extract on experimental periodontitis in mice |
| Allicin | 📋 | ✍ | ⛔ | | 34502071 | Allicin May Promote Reversal of T-Cell Dysfunction in Periodontitis via the PD-1 Pathway |
| Black Tea | 📋 | ✍ | ⛔ | | 37273306 | Anticariogenic Activity of Black Tea: An In Vivo Study |
| Boric Acid | 📋 | ✍ | ⛔ | | 38764161 | Subgingival 0.75% boric acid vs 1% povidone-iodine adjunctive to subgingival instrumentation in stage II and III periodontitis-A double-blind randomized clinical trial |
| CAPE | 📋 | | | | 39981044 | Caffeic acid phenethyl ester inhibits multispecies biofilm formation and cariogenicity |
| Ellagic Acid | 📋 | ✍ | ⛔ | | 40578942 | Cytotoxic and Metalloproteinase-inhibitory Effects of Ellagic Acid Against Oral Squamous Cell Carcinoma |
| Fisetin | 📋 | ✍ | ⛔ | | 39755534 | Exploring the Molecular Mechanisms of Fisetin in Treating Periodontitis Through Multiomics and Network Pharmacology |
| Fucoidan | 📋 | ✍ | ⛔ | | 37648299 | Fucoidan Enhances Cisplatin-induced Effects on SCC-25 Human Oral Cancer Cells by Inhibiting the PI3K/AKT Pathway |
| L-Arginine | 📋 | ✍ | ⛔ | | 40449826 | Microscale analyses of arginine's effect on oral biofilms |
| Piperine | 📋 | ✍ | ⛔ | | 37762259 | Piperine Induces Apoptosis and Autophagy in HSC-3 Human Oral Cancer Cells by Regulating PI3K Signaling Pathway |
| CoQ10 | 📋 | ✍ | ⛔ | | 37480004 | Clinical and biochemical assessment of the effect of topical use of coenzyme Q10 versus topical corticosteroid in management of symptomatic oral lichen planus: randomized controlled clinical trial |
| Crocin | 📋 | ✍ | ⛔ | | 36705490 | Osteogenic effect of crocin in human periodontal ligament stem cells via Wnt/β-catenin signaling |
| Ginger | 📋 | ✍ | ⛔ | | 38888067 | Zingiber officinale promotes autophagy and apoptosis in human oral cancer through the C/EBP homologous protein |
| Goji Berry | 📋 | ✍ | ⛔ | | 40175831 | Mechanism of Lycium barbarum in treating periodontitis based on network pharmacology, molecular docking, and experimental validation |
| Milk Thistle | 📋 | ✍ | ⛔ | | 34968721 | Milk thistle (Silybum marianum (L.)Gaertn.): An overview about its pharmacology and medicinal uses with an emphasis on oral diseases |
| Nobiletin | 📋 | ✍ | | | 40348029 | Epigallocatechin gallate with nobiletin as a novel combination therapy to induce autophagy and apoptosis in oral cancer |
| Postbiotics | 📋 | | | | 40066530 | Postbiotics and Dental Caries: A Systematic Review |
| Prebiotics | 📋 | ✍ | ⛔ | | 40199865 | Probiotics and prebiotics: new treatment strategies for oral potentially malignant disorders and gastrointestinal precancerous lesions |
| Silibinin | 📋 | ✍ | | | 37476191 | Silibinin induces oral cancer cell apoptosis and reactive oxygen species generation by activating the JNK/c-Jun pathway |
| Sulforaphane | 📋 | ✍ | ⛔ | | 40466615 | Novel therapeutic approach in periodontitis: Sulforaphane attenuates disease progression via Nrf2-mediated antioxidant defense |
| Xylitol | 📋 | ✍ | ⛔ | | 38430364 | The effect of xylitol chewing gums and candies on caries occurrence in children: a systematic review with special reference to caries level at study baseline |
| Acemannan | 📋 | | | | 28477996 | Stimulation of Dentin Regeneration by Using Acemannan in Teeth with Lipopolysaccharide-induced Pulp Inflammation |
| Cocoa | 📋 | ✍ | ⛔ | | 39630805 | Anti-Osteoclastogenesis Potential of Cocoa Pod Husk (Theobroma cacao L.) Extract: In Silico and In Vivo Study |
| Diosgenin | 📋 | | | | 40542767 | Anti- Cancer Potential of Diosgenin, a Steroidal Saponin, against Human Oral Cancer Cells |
| Food | 📋 | | | | 40227635 | Beyond Genetics: Exploring Lifestyle, Microbiome, and Social Determinants in Oral Cancer Development |
| Gallic Acid | 📋 | | ⛔ | | 40107001 | Gallic acid promotes M2 macrophage polarization through mitochondrial oxidative phosphorylation in periodontitis |
| Ginseng | 📋 | ✍ | ⛔ | | 38597078 | Potential mechanism of ginseng in the treatment of periodontitis based on network pharmacology and molecular docking |
| Lactobacillus plantarum | 📋 | | ⛔ | | 38668014 | Effect of Probiotics Lactobacillus rhamnosus and Lactobacillus plantarum on Caries and Periodontal Diseases: A Systematic Review |
| Mulberry | 📋 | | ⛔ | | 40390823 | Efficacy of Black Mulberry Mouthwash for Prevention of Chemotherapy-Induced Oral Mucositis: A Double-Blind Randomized Clinical Trial |
| Olive Oil | 📋 | ✍ | ⛔ | | 38826610 | Effectiveness of Microneedling Technique Using Olive Oil on the Severity of Gingival Inflammation and Plaque Accumulation: A Randomised Controlled Trial |
| Peppermint Essential Oil | 📋 | ✍ | ⛔ | | 36864527 | Prevention of radiotherapy-related oral mucositis with zinc and polyherbal mouthwash: a double-blind, randomized clinical trial |
| Reishi Mushrooms | 📋 | ✍ | ⛔ | | 38967207 | Oral Administration of Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Extract Protects Gingival Tissues against Proinflammatory TNF-α and Oxidative Stress in Periodontitis Model Rats |
| Roselle | 📋 | ✍ | ⛔ | | 38376437 | Antioxidant and Antineoplastic Activities of Hibiscus sabdariffa Linn. Petal Extracts against Oral Squamous Cell Carcinoma Cell Line |
| Skullcap | 📋 | ✍ | ⛔ | | 39224355 | Preliminary investigation on the mechanism of anti-periodontitis effect of Scutellariae Radix based on bioinformatics analysis and in vitro verification |
| Theaflavins | 📋 | ✍ | | | 34698557 | Effect of Theaflavin on Oral Bacteria in Japanese Subjects: A Randomized, Placebo-Controlled, Double-Blind Study |
| Antioxidants | 📋 | | ⛔ | | 40413422 | Association between composite dietary antioxidant index and the prevalence of periodontitis: results from NHANES 2009-2014 |
| Black Tea Polyphenols | 📋 | | | | 36008552 | Prevention of carcinogen-induced oral cancers by polymeric black tea polyphenols via modulation of EGFR-Akt-mTOR pathway |
| Blueberry | 📋 | ✍ | ⛔ | | 37375955 | The Protective Role of Cranberries and Blueberries in Oral Cancer |
| Carnosic Acid | 📋 | | | | 39583274 | Antibacterial efficacy of carnosic acid as an intracanal medicament against Enterococcus faecalis: Quantitative polymerase chain reaction study |
| Dihydroquercetin | 📋 | | | | 39824049 | Preventive effects of taxifolin on dental caries in vitro and in vivo |
| Echinacea | 📋 | ✍ | ⛔ | | 39092399 | Formulation of Neem and Echinacea Gel for Oral Health Along With the Evaluation of Antimicrobial, Cytotoxic, Anti-inflammatory, and Free Radical Scavenging Activity: An In Vitro Study |
| Garlic | 📋 | ✍ | ⛔ | | 33437712 | Clinical Quantitative Antibacterial Potency of Garlic-Lemon Against Sodium Hypochlorite in Infected Root Canals: A Double-blinded, Randomized, Controlled Clinical Trial |
| Genistein | 📋 | ✍ | ⛔ | | 40224091 | Uses of soybean isoflavonoids in dentistry: A literature review |
| Glycyrrhizic Acid | 📋 | ✍ | ⛔ | | 34953035 | Glycyrrhizin regulates rat TMJOA progression by inhibiting the HMGB1-RAGE/TLR4-NF-κB/AKT pathway |
| Graviola | 📋 | ✍ | ⛔ | | 40511168 | Exploring the Therapeutic Potential of Hanuman Phal (Annona muricata) in the Adjunctive Treatment of Oral Cancer: A Review |
| Indian Gooseberry | 📋 | | ⛔ | | 38922243 | Phyllanthus emblica fruit extract alleviates halitosis and reduces the inflammatory response to oral bacteria |
| Iodine | 📋 | ✍ | ⛔ | | 39503277 | Iodine deficiency and its association with periodontitis: A randomized controlled triple-blinded clinical study |
| Kaempferol | 📋 | ✍ | ⛔ | | 40220409 | Kaempferol combats the osteogenic differentiation damage of periodontal ligament stem cells in periodontitis via regulating EphrinB2-mediated PI3K/Akt and P38 pathways |
| Lemongrass Essential Oil | 📋 | ✍ | ⛔ | | 37534506 | Comparative Evaluation of 0.25% Lemongrass Oil Mouthwash and 0.2% Chlorhexidine Mouthwash in Fixed Orthodontic Patients Suffering from Gingivitis |
| Mangiferin | 📋 | | ⛔ | | 39049631 | Mechanism of mangiferin in the treatment of oral submucous fibrosis based on Gene Expression Omnibus database chip mining combined with network pharmacology and molecular docking |
| Marigold | 📋 | ✍ | ⛔ | | 29368902 | [Action of Calendula officinalis essence on bone preservation after the extraction] |
| Papain | 📋 | ✍ | ⛔ | | 40136760 | Effects of Bromelain and Papain in Tooth Whitening and Caries Removal: A Literature Review |
| Peony | 📋 | | ⛔ | | 37601076 | Efficacy and safety of total glucosides of paeony in the treatment of recurrent aphthous ulcers: a single-center, double-blind, randomized, placebo-controlled clinical trial |
| Sage | 📋 | ✍ | ⛔ | | 38765348 | Clinical Effectiveness of Salvia officinalis in Periodontitis: A Split-Mouth Randomized Controlled Trial |
| Spirulina | 📋 | ✍ | ⛔ | | 40410376 | Effect of spirulina platensis algae purified bioactive peptides on wound healing after periodontal flap surgery: a randomized clinical trial |
| Vitamin B2 | 📋 | ✍ | ⛔ | | 39861682 | Riboflavin- and Hypericin-Mediated Antimicrobial Photodynamic Therapy as Alternative Treatments for Oral Candidiasis: A Systematic Review |
| Vitamins | 📋 | | | | 39935806 | Hypovitaminosis and its association with recurrent aphthous stomatitis: a comprehensive review of clinical correlations and diagnostic considerations |
| Arjuna | 📋 | ✍ | ⛔ | | 40230946 | Terminalia arjuna: An overview of its magical properties |
| Artemisinin | 📋 | | | | 37699886 | Artemisinins inhibit oral candidiasis caused by Candida albicans through the repression on its hyphal development |
| Astragalosides | 📋 | ✍ | ⛔ | | 39167929 | Astragaloside IV inhibits the proliferation, migration, invasion, and epithelial-mesenchymal transition of oral cancer cells by aggravating autophagy |
| Beta-Cryptoxanthin | 📋 | | | | 37049698 | Anti-Inflammatory Effects of β-Cryptoxanthin on 5-Fluorouracil-Induced Cytokine Expression in Human Oral Mucosal Keratinocytes |
| Catechins | 📋 | | | | 39060994 | Association between flavonoids intake and dental caries in children and adolescents: a cross-sectional study from the NHANES database |
| Chlorogenic Acid | 📋 | ✍ | ⛔ | | 39533555 | Network pharmacology and molecular docking to explore the potential molecular mechanism of chlorogenic acid treatment of oral squamous cell carcinoma |
| Clove | 📋 | | ⛔ | | 33866666 | A randomized clinical study to examine the oral hygiene efficacy of a novel herbal toothpaste with zinc over a 6 month period |
| Clove Essential Oil | 📋 | | ⛔ | | 34633113 | In vitro inhibition of a multispecies oral cavity biofilm by Syzygium aromaticum essential oil |
| Dioscin | 📋 | | | | 39744574 | Targeting the BMI1-Noxa axis by Dioscin induces apoptosis in oral squamous cell carcinoma cells |
| Eicosapentaenoic Acid | 📋 | ✍ | ⛔ | | 36749095 | Effect of local administration of eicosapentaenoic acid on the jaw-opening reflex in rats |
| Eucalyptus | 📋 | ✍ | ⛔ | | 36865731 | Comparative Evaluation of Antimicrobial Efficacy of Sodium Hypochlorite, Triphala, Eucalyptus, and Carvacrol against Enterococcus faecalis: An In Vitro study |
| Ginger extract | 📋 | ✍ | ⛔ | | 35384365 | Effects of ginger (Zingiber officinale) on gingival fibroblasts: An in vitro study |
| Glucosamine | 📋 | ✍ | ⛔ | | 38867545 | Efficiency of Glucosamine in Treating Temporomandibular Joint Osteoarthritis: A Systematic Review |
| Hesperetin | 📋 | | | | 40130014 | In vitro study of effects of hesperetin on human oral cancer using KB cell model |
| Icariin | 📋 | ✍ | | | 39388889 | Icariin suppresses osteogenic differentiation and promotes bone regeneration in Porphyromonas gingivalis-infected conditions through EphA2-RhoA signaling pathway |
| Lavender Essential Oil | 📋 | ✍ | ⛔ | | 36629536 | Antinociceptive and anxiolytic-like effects of Lavandula angustifolia essential oil on rat models of orofacial pain |
| Myrtle | 📋 | ✍ | ⛔ | | 39372348 | The Efficacy of Populus euphratica and Myrtus communis Herbal Mouthwash on Gingivitis in Pediatric Patients Diagnosed Clinically and with Photometric CIELab Analysis: An In Vivo Randomized Double-blind Clinical Study |
| Paeonol | 📋 | | | | 40197308 | Paeonol inhibits the Glycolysis in oral squamous cell carcinoma though suppressing NAT10-mediated ac4C modification |
| Polyphenols | 📋 | | | | 35011503 | Propolis and Diet Rich in Polyphenols as Cariostatic Agents Reducing Accumulation of Dental Plaque |
| Pterostilbene | 📋 | ✍ | ⛔ | | 35340874 | Pterostilbene attenuates the proliferation and differentiation of TNF-α-treated human periodontal ligament stem cells |
| Puerarin | 📋 | ✍ | ⛔ | | 40312745 | Puerarin relives inflammation, bone destruction and facilitates osteogenic differentiation in periodontitis by enhancing mitochondrial autophagy via activating mitochondrial Mitofusin 2 |
| Punicalagin | 📋 | ✍ | ⛔ | | 39994845 | Punicalagin ameliorates lipopolysaccharide-induced inflammatory response in dental pulp cells via inhibition of the NF-?B/Wnt5a-ROR2 pathway |
| Raspberry | 📋 | ✍ | ⛔ | | 39502024 | Black raspberry modulates cecal and oral microbiome at the early stage of a dibenzo[def,p]chrysene-induced murine oral cancer model |
| Vitamin B Complex | 📋 | | ⛔ | | 40218924 | The Role of Vitamin B Complex in Periodontal Disease: A Systematic Review Examining Supplementation Outcomes, Age Differences in Children and Adults, and Aesthetic Changes |
| Vitamin B12 | 📋 | ✍ | ⛔ | | 40214355 | Nutritional deficiencies in oral potentially malignant disorders and oral squamous cell carcinoma |
| Withaferin A | 📋 | | | | 33202766 | Low Dose Combined Treatment with Ultraviolet-C and Withaferin a Enhances Selective Killing of Oral Cancer Cells |
| Aloe-Emodin | 📋 | | | | 36302645 | Effects of aloe-emodin on alveolar bone in Porphyromonas gingivalis-induced periodontitis rat model: a pilot study |
| Anethole | 📋 | | | | 39689117 | Modulation of signature cancer-related genes in oral cancer cells (Ca9-22) by anethole treatment: Insights into therapeutic potential |
| Apple | 📋 | | ⛔ | | 29970630 | Effect of crude apple extract on the cariogenic factors of Streptococcus mutans: An in vitro study |
| Asiatic Acid | 📋 | | | | 39253601 | Asiatic acid reduces lipopolysaccharides-induced pulp inflammation through activation of nuclear factor erythroid 2-related factor 2 in rats |
| Avocado | 📋 | ✍ | ⛔ | | 31508794 | Effect of avocado/soybean unsaponifiables on periodontal repair in rats with arthritis and induced periodontitis |
| Beta-Carotene | 📋 | ✍ | ⛔ | | 26423734 | Higher Intakes of Fruits and Vegetables, β-Carotene, Vitamin C, α-Tocopherol, EPA, and DHA Are Positively Associated with Periodontal Healing after Nonsurgical Periodontal Therapy in Nonsmokers but Not in Smokers |
| Betaine | 📋 | ✍ | ⛔ | | 39408625 | Betaine Induces Apoptosis and Inhibits Invasion in OSCC Cell Lines |
| Bitter Melon | 📋 | ✍ | ⛔ | | 39759601 | Assessment of the Antimicrobial Effect of Momordica charantia (Bitter Gourd Oil) on Periodontal Pathogens: An In Vitro Study |
| Boswellic Acid | 📋 | ✍ | ⛔ | | 39841429 | Boswellic acid exerts anti-tumor effect in oral squamous cell carcinoma by inhibiting PI3K/AKT1 mediated signaling pathway |
| Caffeine | 📋 | ✍ | ⛔ | | 40084800 | Short-Term Dietary Caffeine Intake for Alleviating Symptoms of Burning Mouth Syndrome: A Randomised Controlled Comparison With Alpha-Lipoic Acid |
| Calcium | 📋 | ✍ | ⛔ | | 36618706 | Dietary vitamin D and calcium and periodontitis: A population-based study |
| Cardamonin | 📋 | | | | 39242879 | Mechanism of apoptosis in oral squamous cell carcinoma promoted by cardamonin through PI3K/AKT signaling pathway |
| Cherry | 📋 | | ⛔ | | 33497417 | Effects of a tart cherry (Prunus cerasus L.) phenolic extract on Porphyromonas gingivalis and its ability to impair the oral epithelial barrier |
| Chrysin | 📋 | ✍ | ⛔ | | 36555388 | Chrysin Induces Apoptosis via the MAPK Pathway and Regulates ERK/mTOR-Mediated Autophagy in MC-3 Cells |
| Citral | 📋 | | | | 37244090 | Orofacial anti-hypernociceptive effect of citral in acute and persistent inflammatory models in rats |
| Coptis Chinensis | 📋 | | ⛔ | | 38729536 | Coptidis rhizoma extract alleviates oropharyngeal candidiasis by gC1qR-EGFR/ERK/c-fos axis-induced endocytosis of oral epithelial cells |
| Daidzein | 📋 | ✍ | ⛔ | | 40224091 | Uses of soybean isoflavonoids in dentistry: A literature review |
| Fiber | 📋 | ✍ | ⛔ | | 37764817 | Role of Dietary Fibre in Managing Periodontal Diseases-A Systematic Review and Meta-Analysis of Human Intervention Studies |
| Fucoxanthin | 📋 | ✍ | ⛔ | | 39679254 | Fucosterol and Fucoxanthin Enhance Dentin Collagen Stability and Erosion Resistance Through Crosslinking and MMP Inhibition |
| Gingerol | 📋 | ✍ | | | 34697150 | [6]-Gingerol Suppresses Oral Cancer Cell Growth by Inducing the Activation of AMPK and Suppressing the AKT/mTOR Signaling Pathway |
| Guava | 📋 | | ⛔ | | 35906612 | The effect of hydroalcoholic extract of Psidium guajava L. on experimentally induced oral mucosal wound in rat |
| Honokiol | 📋 | | | | 33980461 | Honokiol inhibits arecoline-induced oral fibrogenesis through transforming growth factor-β/Smad2/3 signaling inhibition |
| Horsetail Grass | 📋 | ✍ | ⛔ | | 39570913 | Antinociceptive effect of Equisetum arvense extract on the stomatitis hamster model |
| Isoliquiritigenin | 📋 | | | | 40376593 | Isoliquiritigenin Alleviates Periodontitis by Suppressing Inflammation via NF-κB Signaling Pathway of Immune Cell |
| Lemon Essential Oil | 📋 | ✍ | ⛔ | | 35080078 | The Effect of Lemon Essential Oil on Halitosis |
| Linalool | 📋 | | ⛔ | | 38096923 | Analgesic effect of linalool odor on oral ulcerative mucositis-induced pain in rats |
| Mango Leaf | 📋 | | ⛔ | | 28611324 | Comparative evaluation of Mangifera indica leaf mouthwash with chlorhexidine on plaque accumulation, gingival inflammation, and salivary streptococcal growth |
| Mastic | 📋 | ✍ | ⛔ | | 37865987 | Sialagogic Effects Through Olfactory Stimulation with Mastic Resin and α-pinene Volatiles in vivo |
| Matcha Tea | 📋 | | | | 38771061 | Multimodal inhibitory effect of matcha on Porphyromonas gingivalis |
| MSM | 📋 | ✍ | ⛔ | | 39819670 | Investigation of the preventive effect of methylsulfonylmethane on alveolar bone loss and oxidative stress in a rat model of periodontitis |
| Myrrh | 📋 | ✍ | ⛔ | | 36714089 | Effect of an herbal mouthwash on periodontal indices in patients with plaque-induced gingivitis: A cross-over clinical trial |
| Naringin | 📋 | ✍ | ⛔ | | 39156270 | Exploring the Cytotoxic and Anticancer Potential of Naringin on Oral Cancer Cell Line |
| Nimbolide | 📋 | | | | 39462890 | Nimbolide Induces Cell Apoptosis via Mediating ER Stress-Regulated Apoptotic Signaling in Human Oral Squamous Cell Carcinoma |
| Nutmeg | 📋 | ✍ | ⛔ | | 35959299 | Comparative evaluation of nutmeg mouthwash and 0.2% chlorhexidine gluconate mouthwash on halitosis and plaque control: A randomized clinical trial |
| Ollive Leaf extract | 📋 | ✍ | ⛔ | | 39203568 | Antimicrobial Activity of Olive Leaf Extract to Oral Candida Isolates |
| Oregano Essential Oil | 📋 | ✍ | ⛔ | | 35094612 | Physicochemical characteristics and antimicrobial activity of Origanum vulgare L. essential oil and carvacrol on cariogenic bacteria: an in vitro and in silico study |
| Piperlongumine | 📋 | | | | 38452870 | Anti-cancer agent piperlongumine is an inhibitor of transient receptor potential melastatin 7 channel in oral squamous cell carcinoma |
| Polydatin | 📋 | ✍ | | | 36678905 | Chemopreventive and Anticancer Role of Resveratrol against Oral Squamous Cell Carcinoma |
| Procyanidins | 📋 | | ⛔ | | 39500084 | Procyanidin B2 targeted CCR7 expression to inhibit the senescence-associated secretory phenotype through the NF-κB pathway to promote osteogenic differentiation of periodontal ligament stem cells in periodontitis |
| Rapamycin | 📋 | ✍ | | | 38276004 | Rapamycin as a Potential Alternative Drug for Squamous Cell Gingiva Carcinoma (Ca9-22): A Focus on Cell Cycle, Apoptosis and Autophagy Genetic Profile |
| Rosmarinic Acid | 📋 | ✍ | | | 40064225 | Unraveling rosmarinic acid anticancer mechanisms in oral cancer malignant transformation |
| Selenium | 📋 | ✍ | ⛔ | | 40325319 | Potential Relationship Between Decreased Serum Selenium Levels and Oxidative Stress in Periodontitis Stage III-IV |
| Shogaol | 📋 | | | | 38481719 | Prophylactic and therapeutic effects of (6)-shogaol on alveolar bone loss in experimental periodontitis |
| Silymarin | 📋 | ✍ | ⛔ | | 38356030 | Antifibrotic effect of silymarin on arecoline-induced fibrosis in primary human buccal fibroblasts: an in silico and in vitro analysis |
| St. Johns Wort | 📋 | ✍ | ⛔ | | 33964648 | Evaluation of the chemopreventive effects of Hypericum perforatum L on DMBA-applied rat oral mucosa |
| Tanshinone | 📋 | | | | 37670974 | Tanshinone IIA inhibits cell viability and promotes PUMA-mediated apoptosis of oral squamous cell carcinoma |
| Tea | 📋 | | | | 39338082 | Diet and Oral Squamous Cell Carcinoma: A Scoping Review |
| Theobromine | 📋 | ✍ | ⛔ | | 40102825 | Association of dietary intake of theobromine with periodontitis: NHANES 2009-2014 |
| Thyme | 📋 | ✍ | ⛔ | | 36760146 | EFFECTS OF THYME ON HALITOSIS IN GINGIVITIS PATIENTS Can Thyme Mouthwash Prevent Halitosis - a Randomized Trial? |
| Thyme Essential Oil | 📋 | | ⛔ | | 33625248 | Antibiofilm effects of Thymus vulgaris and Hyptis spicigera essential oils on cariogenic bacteria |
| Thymol | 📋 | ✍ | ⛔ | | 34867378 | In Vitro and In Vivo Anti-infective Potential of Thymol Against Early Childhood Caries Causing Dual Species Candida albicans and Streptococcus mutans |
| Toothache Plant | 📋 | | | | 37671677 | The potential of Acmella oleracea as a nutraceutical source for the symptomatic treatment of Burning Mouth Syndrome |
| Tribulus Terrestris | 📋 | ✍ | ⛔ | | 39574561 | Antibacterial and antibiofilm activities of tribulus terrestris methanolic extract against Streptococcus mutans, Streptococcus sobrinus, and Lactobacillus acidophilus: An in vitro study |
| Acacetin | 📋 | | | | 32797769 | Protective effect of acacetin in human periodontal ligament cells via regulation of autophagy and inflammation |
| Acai Berry | 📋 | ✍ | ⛔ | | 40343791 | Evaluation of alveolar bone preservation and oxidative stress reduction with açai in Wistar rats with induced apical periodontitis |
| Anthocyanins | 📋 | ✍ | ⛔ | | 25658905 | Anthocyanins From Black Rice (Oryza Sativa L.) Demonstrate Antimetastatic Properties by Reducing MMPs and NF-κB Expressions in Human Oral Cancer CAL 27 Cells |
| Apple Polyphenols | 📋 | | ⛔ | | 35281303 | Thinned-Young Apple Polyphenols Inhibit Halitosis-Related Bacteria Through Damage to the Cell Membrane |
| Arctigenin | 📋 | | | | 30884781 | Arctigenin Reduces Myofibroblast Activities in Oral Submucous Fibrosis by LINC00974 Inhibition |
| Arnica | 📋 | ✍ | ⛔ | | 31952199 | Anti-Bacterial and Anti-Inflammatory Effects of Toothpaste with Swiss Medicinal Herbs towards Patients Suffering from Gingivitis and Initial Stage of Periodontitis: from Clinical Efficacy to Mechanisms |
| Ashwagandha | 📋 | ✍ | ⛔ | | 39346383 | Evaluation of Turmeric, Ashwagandha, and Aloe Vera in the Management of Oral Lichen Planus Lesion |
| Asiaticoside | 📋 | | | | 29520784 | Asiaticoside induces osteogenic differentiation of human periodontal ligament cells through the Wnt pathway |
| Balloon Flower | 📋 | ✍ | ⛔ | | 31137477 | In Vitro Effect of the Traditional Medicine Hainosan (Painongsan) on Porphyromonas gingivalis |
| Barberry | 📋 | ✍ | ⛔ | | 37315644 | Buccal spray of standardized Berberis aristata extract causes tumour regression, chemoprotection and downregulation of inflammatory mediators in oral cancer hamster model |
| Beets | 📋 | ✍ | ⛔ | | 34195102 | A Single Dose of Nitrate Increases Resilience Against Acidification Derived From Sugar Fermentation by the Oral Microbiome |
| Bergamot | 📋 | ✍ | ⛔ | | 37748407 | Bergapten exerts a chondroprotective effect in temporomandibular joint osteoarthritis by combining intestinal flora alteration and reactive oxygen species reduction |
| Beta-Glucan | 📋 | ✍ | ⛔ | | 37525561 | Metastasis and immunosuppression promoted by mtDNA and PD-L1 in extracellular vesicles are reversed by WGP β-glucan in oral squamous cell carcinoma |
| Beta-Lapachone | 📋 | | | | 30071298 | β-Lapachone and its iodine derivatives cause cell cycle arrest at G 2/M phase and reactive oxygen species-mediated apoptosis in human oral squamous cell carcinoma cells |
| Beta-Sitosterol | 📋 | ✍ | ⛔ | | 40061693 | Exploring the Role of ?-Sitosterol, Genistein, and Emodin in Periodontal Regeneration |
| Bilberry | 📋 | ✍ | ⛔ | | 34439567 | Bilberry ( Vaccinium myrtillus L.) Powder Has Anticarcinogenic Effects on Oral Carcinoma In Vitro and In Vivo |
| Bitter Orange | 📋 | ✍ | ⛔ | | 31137477 | In Vitro Effect of the Traditional Medicine Hainosan (Painongsan) on Porphyromonas gingivalis |
| Burdock | 📋 | | ⛔ | | 38770307 | Antimicrobial and anti-inflammatory effects of BenTooth: A natural product blend of burdock root, persimmon leaf extracts, and quercetin on periodontal disease |
| Butyrate | 📋 | | ⛔ | | 37775917 | Butyrate Inhibits Dendritic Cell Activation and Alleviates Periodontitis |
| Carnosol | 📋 | | | | 40220028 | Anti-cancer effects of carnosol in DMBA-induced oral experimental carcinogenesis by oncogenic signaling pathways on in vivo and in silico study |
| Cat's Claw | 📋 | ✍ | ⛔ | | 27119588 | Antimicrobial activity and substantivity of Uncaria tomentosa in infected root canal dentin |
| Chokeberry | 📋 | ✍ | ⛔ | | 34846271 | Can the chokeberry juice be used as additional therapy for burning mouth syndrome in menopausal women? |
| Chondroitin | 📋 | ✍ | ⛔ | | 35588467 | Efficacy of the use of chondroitin sulphate and glucosamine for the treatment of temporomandibular joint dysfunction: A systematic review and meta-analysis |
| Coconut | 📋 | | ⛔ | | 38827356 | Remineralization potential of varying concentrations of two plant-based extracts of Cocos nucifera on white spot lesions using SEM and EDAX analysis: An in vitro study |
| Coffee | 📋 | ✍ | ⛔ | | 38333482 | A Comparative Analysis of Three Antioxidants in Addition to Scaling and Root Planing in Stage Three Grade B Periodontitis |
| Cordycepin | 📋 | | | | 38023774 | Cordycepin Induces Apoptosis through JNK-Mediated Caspase Activation in Human OEC-M1 Oral Cancer Cells |
| Coriander Essential Oil | 📋 | ✍ | ⛔ | | 24901768 | Coriandrum sativum L. (Coriander) essential oil: antifungal activity and mode of action on Candida spp., and molecular targets affected in human whole-genome expression |
| D-Limonene | 📋 | ✍ | ⛔ | | 35026511 | Limonene, a citrus monoterpene, non-complexed and complexed with hydroxypropyl-β-cyclodextrin attenuates acute and chronic orofacial nociception in rodents: Evidence for involvement of the PKA and PKC pathway |
| Diosmin | 📋 | ✍ | ⛔ | | 27544550 | Diosmin induce apoptosis through modulation of STAT-3 signaling in 7,12 dimethylbenz(a)anthracene induced harmster buccal pouch carcinogenesis |
| Docosahexaenoic Acid | 📋 | ✍ | ⛔ | | 34699926 | Identification of docosahexaenoic and eicosapentaenoic acids multiple targets facing periodontopathogens |
| Elderberry | 📋 | ✍ | ⛔ | | 35866676 | The Effect of Mouthwash with Sambucus williamsii var. coreana Extract on Halitosis: A Randomised, Double-Blind, Placebo-Controlled Study |
| Emodin | 📋 | | ⛔ | | 40061693 | Exploring the Role of ?-Sitosterol, Genistein, and Emodin in Periodontal Regeneration |
| Eucommia | 📋 | ✍ | ⛔ | | 35932002 | Effect of Eucommia water extract on gingivitis and periodontitis in experimental rats |
| Fenugreek | 📋 | ✍ | ⛔ | | 40450110 | In silico identification of potential inhibitors from fenugreek against the pro-inflammatory cytokine IL-17 and its receptor |
| Fig | 📋 | | ⛔ | | 29657427 | Antibacterial activity of fig leaf ( Ficus carica Linn.) extract against Enterococcus faecalis and its cytotoxicity effects on fibroblast cells |
| Flaxseed | 📋 | ✍ | ⛔ | | 40564926 | Flaxseed Extracts Impact the Cellular Structure of a Keratinocyte Model for Oral Lichen Planus-A Preliminary Study |
| Gardenia | 📋 | | ⛔ | | 34674717 | Huanglianjiedu Decoction as an effective treatment for oral squamous cell carcinoma based on network pharmacology and experimental validation |
| Genipin | 📋 | | | | 40206082 | Genipin attenuates oxidative damage in periodontal tissues by alleviating mitochondrial dysfunction and abnormal glucose uptake through inhibition of UCP2 |
| Ginkgolic Acid | 📋 | | | | 31970286 | Ginkgolic Acid, a SUMO-1 Inhibitor, Inhibits the Progression of Oral Squamous Cell Carcinoma by Alleviating SUMOylation of SMAD4 |
| Ginkgolides | 📋 | | | | 39616730 | The potential immunotherapy effect of Ginkgolide B thwarts oral squamous cell carcinoma progression by targeting the SREBP1/KLK8/CCL22 axis |
| Glabridin | 📋 | | | | 32632823 | Biocompatible combinations of nisin and licorice polyphenols exert synergistic bactericidal effects against Enterococcus faecalis and inhibit NF-κB activation in monocytes |
| Grapefruit extract | 📋 | ✍ | ⛔ | | 39672374 | The potential anti-inflammatory effect of hyaluronic acid gel alone or in combination with grapefruit seed extract on induced periodontitis in mandibular molars of Wistar rats |
| Iron | 📋 | ✍ | ⛔ | | 37408351 | Iron level participates in the pathological damages of dental caries in infant rats by affecting enamel mineralization |
| Kiwifruit | 📋 | ✍ | ⛔ | | 29520772 | The effect of twice daily kiwifruit consumption on periodontal and systemic conditions before and after treatment: A randomized clinical trial |
| Knotweed | 📋 | ✍ | ⛔ | | 30720102 | Autophagy and apoptotic machinery caused by Polygonum cuspidatum extract in cisplatin-resistant human oral cancer CAR cells |
| L-Carnosine | 📋 | ✍ | ⛔ | | 40276606 | Carnosine alleviates oxidative stress to prevent cellular senescence by regulating Nrf2/HO-1 pathway: a promising anti-aging strategy for oral mucosa |
| Lemon | 📋 | | ⛔ | | 33512251 | Effect of Honey-Lemon Spray Versus Benzydamine Hydrochloride Spray on Radiation-Induced Acute Oral Mucositis in Head and Neck Cancer Patients: A Pilot, Randomized, Double-Blind, Active-Controlled Clinical Trial |
| Lime | 📋 | | ⛔ | | 34204096 | Evaluation of Mouthwash Containing Citrus hystrix DC., Moringa oleifera Lam. and Azadirachta indica A. Juss. Leaf Extracts on Dental Plaque and Gingivitis |
| Lingonberry | 📋 | | ⛔ | | 34835994 | Lingonberries-General and Oral Effects on the Microbiome and Inflammation |
| Magnolia | 📋 | ✍ | ⛔ | | 33889369 | The antibacterial effect of Magnolia mouthwash on the levels of salivary Streptococcus mutans in dental plaque: a randomized, single-blind, placebo-controlled trial |
| Myricetin | 📋 | | ⛔ | | 33971542 | Discovery of myricetin as an inhibitor against Streptococcus mutans and an anti-adhesion approach to biofilm formation |
| Noni | 📋 | | ⛔ | | 38004017 | Effect of Plant-Based Mouthwash ( Morinda citrifolia and Ocimum sanctum) on TNF-α, IL-α, IL-β, IL-2, and IL-6 in Gingival Crevicular Fluid and Plaque Scores of Patients Undergoing Fixed Orthodontic Treatment |
| Oak Bark | 📋 | ✍ | ⛔ | | 33895758 | Microbiological aspects of conservative treatment of periodontal disease using gel-based preparations |
| Oolong Tea | 📋 | | ⛔ | | 35873431 | Oolong Tea Consumption and the Risk of Oral Squamous Cell Carcinoma: A Propensity Score-Based Analysis in Southeast China |
| Paeoniflorin | 📋 | | | | 37340760 | Anti-inflammatory and pro-regenerative effects of a monoterpene glycoside on experimental periodontitis in a rat model of diabetes |
| Panax Notoginseng | 📋 | ✍ | ⛔ | | 39957160 | Effect and mechanism of Sanqi () in treating periodontitis |
| Papaya | 📋 | ✍ | ⛔ | | 37283020 | Anticancer Effects of Carica papaya L. and Benzyl Isothiocyanate on an Oral Squamous Cell Carcinoma Cell Line: An In Vitro Study |
| Persimmon | 📋 | | ⛔ | | 40058939 | Intraoral treatment of persimmon tannin, a polyphenol extracted from persimmon, significantly ameliorates gingivitis, plaque and halitosis via directly influence the periodontal bacteria Porphyromonasgulae |
| Proanthocyanidins | 📋 | | | | 36167610 | Efficacy of Proanthocyanidins in Nonsurgical Periodontal Therapy |
| Rosemary | 📋 | ✍ | ⛔ | | 26850813 | Evaluation of the efficacy of a polyherbal mouthwash containing Zingiber officinale, Rosmarinus officinalis and Calendula officinalis extracts in patients with gingivitis: A randomized double-blind placebo-controlled trial |
| Rosemary Essential Oil | 📋 | ✍ | ⛔ | | 34365060 | Advantages of using toothpaste containing propolis and plant oils for gingivitis prevention and oral cavity hygiene in cleft lip/palate patients |
| Salvianolic Acid | 📋 | | | | 31831723 | Salvianolic Acid C Attenuates LPS-Induced Inflammation and Apoptosis in Human Periodontal Ligament Stem Cells via Toll-Like Receptors 4 (TLR4)/Nuclear Factor kappa B (NF-κB) Pathway |
| Soy Isoflavones | 📋 | ✍ | ⛔ | | 40224091 | Uses of soybean isoflavonoids in dentistry: A literature review |
| Spermidine | 📋 | | | | 39657843 | Spermidine alleviates diabetic periodontitis by reversing human periodontal ligament stem cell senescence via mitophagy |
| Tangeretin | 📋 | | | | 38022093 | Tangeretin's Anti-apoptotic Signaling Mechanisms in Oral Cancer Cells: In Vitro Anti-cancer Activity |
| Taurine | 📋 | ✍ | ⛔ | | 40153370 | Taurine levels in periodontitis: A pilot study |
| Tea Polyphenols | 📋 | | | | 30640129 | Tea polyphenols protect gingival keratinocytes against TNF-α-induced tight junction barrier dysfunction and attenuate the inflammatory response of monocytes/macrophages |
| Vitamin B6 | 📋 | ✍ | ⛔ | | 39994649 | Vitamin B6 status, type 2 diabetes mellitus, and periodontitis: evidence from the NHANES database 2009-2010 |
| Vitamin B9 | 📋 | ✍ | ⛔ | | 40214355 | Nutritional deficiencies in oral potentially malignant disorders and oral squamous cell carcinoma |
| Vitamin K | 📋 | ✍ | ⛔ | | 37198606 | Association of vitamin K, fibre intake and progression of periodontal attachment loss in American adults |
| Wormwood | 📋 | ✍ | ⛔ | | 39767582 | Investigating the Cytotoxic Effects of Artemisia absinthium Extract on Oral Carcinoma Cell Line |
| Yohimbine | 📋 | ✍ | | | 39412169 | Estimating Anticancer Effects of Yohimbine in DMBA-Induced Oral Carcinogenesis Hamster Model: Utilizing Biochemical and Immunohistochemical Techniques |
| Aloin | 📋 | | | | 39853490 | Aloin remodels the cell wall of Candida albicans to reduce its hyphal virulence against oral candidiasis |
| Alpha-Linolenic Acid | 📋 | ✍ | ⛔ | | 38068849 | Protective Effect of Alpha-Linolenic Acid on Human Oral Squamous Cell Carcinoma Metastasis and Apoptotic Cell Death |
| Amygdalin | 📋 | ✍ | ⛔ | | 31110425 | Effect of Amygdalin on Oral Cancer Cell Line: An in vitro Study |
| Angelica | 📋 | ✍ | ⛔ | | 35682836 | Butylidenephthalide Abrogates the Snail-Induced Cancer Stemness in Oral Carcinomas |
| Anthocyanidins | 📋 | | | | 39060994 | Association between flavonoids intake and dental caries in children and adolescents: a cross-sectional study from the NHANES database |
| Apricot Kernels | 📋 | ✍ | ⛔ | | 31110425 | Effect of Amygdalin on Oral Cancer Cell Line: An in vitro Study |
| Arachidonic Acid | 📋 | ✍ | ⛔ | | 39519322 | Trans, Trans-Farnesol Enhances the Anti-Bacterial and Anti-Biofilm Effect of Arachidonic Acid on the Cariogenic Bacteria Streptococcus mutans and Streptococcus sobrinus |
| Aspirin | 📋 | | ⛔ | | 37787044 | Adjunctive use of omega-3 fatty acids in combination with low-dose aspirin in periodontitis: Systematic review and meta-analysis |
| Astragalus Root | 📋 | ✍ | ⛔ | | 40004956 | The Multi-Target Action Mechanism for the Anti-Periodontitis Effect of Astragali radix Based on Bioinformatics Analysis and In Vitro Verification |
| Bacopa Monnieri | 📋 | ✍ | ⛔ | | 37951147 | Anticancer activity of Bacopa monnieri through apoptosis induction and mitophagy-dependent NLRP3 inflammasome inhibition in oral squamous cell carcinoma |
| Basil | 📋 | ✍ | ⛔ | | 31942110 | Antifungal activity of solvent extracts of Piper betle and Ocimum sanctum Linn on Candida albicans: An in vitro comparative study |
| Basil Essential Oil | 📋 | ✍ | ⛔ | | 29207708 | In Vitro Anti-Cariogenic Plaque Effects of Essential Oils Extracted from Culinary Herbs |
| Bee Venom | 📋 | ✍ | ⛔ | | 35624686 | Apitherapy and Periodontal Disease: Insights into In Vitro, In Vivo, and Clinical Studies |
| Berries | 📋 | | | | 33466319 | Effect of a Berry Polyphenolic Fraction on Biofilm Formation, Adherence Properties and Gene Expression of Streptococcus mutans and Its Biocompatibility with Oral Epithelial Cells |
| Betulinic Acid | 📋 | | | | 35538811 | Betulinic acid exerts anti-inflammatory activity in human periodontal ligament cells stimulated with lipopolysaccharide and/or high glucose |
| Biochanin A | 📋 | | | | 39364853 | Investigating the Anticancer Potential of Biochanin A in KB Oral Cancer Cells Through the NFκB Pathway |
| Blackberry | 📋 | | ⛔ | | 33435253 | Chemical Composition, Antioxidant and Antimicrobial Activity of Raspberry, Blackberry and Raspberry-Blackberry Hybrid Leaf Buds |
| Blackcurrant | 📋 | ✍ | ⛔ | | 22985050 | Anti-viral and anti-bacterial activities of an extract of blackcurrants (Ribes nigrum L.) |
| Calcium D-Glucarate | 📋 | ✍ | ⛔ | | 20393005 | Calcium glucarate inhibits DMBA-induced oral carcinogenesis in the hamster: histomorphometric evaluation |
| Capsanthin | 📋 | | | | 36141454 | The Utility of Capsicum annuum L. in Internal Medicine and In Dentistry: A Comprehensive Review |
| Cardamom | 📋 | ✍ | ⛔ | | 31430531 | Antibacterial and anti-inflammatory activities of cardamom (Elettaria cardamomum) extracts: Potential therapeutic benefits for periodontal infections |
| Chaga Mushrooms | 📋 | ✍ | ⛔ | | 38720012 | Chaga mushroom extract suppresses oral cancer cell growth via inhibition of energy metabolism |
| Chamomile Essential Oil | 📋 | ✍ | ⛔ | | 30820080 | A relative assessment of essential oil of Chrysopogon zizanioides and Matricaria chamomilla along with calcium hydroxide and chlorhexidine gel against Enterococcus faecalis in ex vivo root canal models |
| Chili Pepper | 📋 | | ⛔ | | 35600864 | The Antifibrotic and the Anticarcinogenic Activity of Capsaicin in Hot Chili Pepper in Relation to Oral Submucous Fibrosis |
| Chitosan | 📋 | ✍ | ⛔ | | 35214037 | General Characteristics, Biomedical and Dental Application, and Usage of Chitosan in the Treatment of Temporomandibular Joint Disorders: A Narrative Review |
| Chrysanthemum | 📋 | ✍ | ⛔ | | 36777434 | Effect of ethanol extract from Chrysanthemum cinerariifolium leaves on Ki-67 proliferation and dysplasia severity in a rat model of oral squamous cell carcinoma |
| Citrus Fruits | 📋 | | ⛔ | | 29753688 | Citrus fruits intake and oral cancer risk: A systematic review and meta-analysis |
| Clary Sage Essential Oil | 📋 | ✍ | ⛔ | | 28093319 | Anti-inflammatory effect of the Salvia sclarea L. ethanolic extract on lipopolysaccharide-induced periodontitis in rats |
| Coconut Protein | 📋 | | | | 40085302 | Anti-inflammatory and antimicrobial efficacy of coconut oil for periodontal pathogens: a triple-blind randomized clinical trial |
| Collagen | 📋 | ✍ | | | 36364735 | Impact of a Specific Collagen Peptide Food Supplement on Periodontal Inflammation in Aftercare Patients-A Randomised Controlled Trial |
| Copper | 📋 | ✍ | ⛔ | | 36185249 | A pro-oxidant combination of resveratrol and copper down-regulates hallmarks of cancer and immune checkpoints in patients with advanced oral cancer: Results of an exploratory study (RESCU 004) |
| Cordyceps | 📋 | ✍ | ⛔ | | 36072973 | Network Pharmacology and Molecular Docking Analysis Explores the Mechanisms of Cordyceps s inensis in the Treatment of Oral Lichen Planus |
| Coriander | 📋 | | ⛔ | | 31747377 | Vietnamese coriander inhibits cell proliferation, survival and migration via suppression of Akt/mTOR pathway in oral squamous cell carcinoma |
| Crocetin | 📋 | | | | 33133459 | Central H 2 histaminergic and alpha-2 adrenergic receptors involvement in crocetin-induced antinociception in orofacial formalin pain in rats |
| Cryptotanshinone | 📋 | | | | 36704921 | Cryptotanshinone inhibits oral squamous cell carcinoma through the autophagic pathway |
| Cyanidin | 📋 | ✍ | | | 40304465 | Inhibitory effect of plant flavonoid cyanidin on oral microbial biofilm |
| D-Mannose | 📋 | ✍ | ⛔ | | 36031720 | D-Mannose alleviated alveolar bone loss in experimental periodontitis mice via regulating the anti-inflammatory effect of amino acids |
| Dairy | 📋 | | | | 37650016 | Influence of dairy products consumption on oral cancer risk: A meta-analysis |
| Date | 📋 | | ⛔ | | 35233390 | Cytotoxic and Antioxidant Effects of Phoenix dactylifera L. (Ajwa Date Extract) on Oral Squamous Cell Carcinoma Cell Line |
| DHEA | 📋 | ✍ | ⛔ | | 38885603 | Dehydroepiandrosterone attenuated the immune escape of oral squamous cell carcinoma through NF-κB p65/miR-15b-5p/B7-H4 axis |
| Dihydroartemisinin | 📋 | | | | 34847839 | Dihydroartemisinin represses oral squamous cell carcinoma progression through downregulating mitochondrial calcium uniporter |
| Equol | 📋 | ✍ | ⛔ | | 38749724 | Clinical effect of equol supplementation in the treatment of desquamative gingivitis with 1-year follow-up |
| Escin | 📋 | ✍ | ⛔ | | 22895831 | Escin inhibits lipopolysaccharide-induced inflammation in human periodontal ligament cells |
| Eucalyptus Essential Oil | 📋 | | ⛔ | | 38389967 | Efficacy of a Eucalyptus oil-based dentifrice in reducing plaque and gingival bleeding scores - A randomized clinical crossover study |
| Evening Primrose Oil | 📋 | ✍ | ⛔ | | 15898373 | Evening primrose oil effects on osteoclasts during tooth movement |
| Fatty Acids | 📋 | | | | 39864010 | Association of dietary and plasma fatty acids with periodontitis: Results from the 2009-2014 National Health and Nutrition Examination Survey and Mendelian randomization study |
| Ferulic Acid | 📋 | ✍ | ⛔ | | 39370400 | Structural studies and functional validation of Eugenol and Ferulic acid against Enterococcus faecalis Sortase A |
| Fish Collagen | 📋 | ✍ | ⛔ | | 35934799 | Marine collagen peptides: A novel biomaterial for the healing of oral mucosal ulcers |
| Fish Oil | 📋 | ✍ | ⛔ | | 22809098 | Combination of Astaxanthin and Fish Oil Supplementation Alters Antioxidant Enzyme Profile of Dental Pulp Tissue |
| Flavonoids | 📋 | | ⛔ | | 35331090 | Efficacy of Flavonoids in Combating Fluconazole Resistant Oral Candidiasis |
| Flaxseed Oil | 📋 | ✍ | ⛔ | | 35485674 | Clinical Assessment of Efficacy of Omega 3 in Oral Submucous Fibrosis Patients - A Randomized Controlled Trial |
| Folate | 📋 | ✍ | ⛔ | | 30558282 | Serum Nutrient Levels and Aging Effects on Periodontitis |
| Frankincense Essential Oil | 📋 | | ⛔ | | 35807419 | Effects of Frankincense Compounds on Infection, Inflammation, and Oral Health |
| Fruits | 📋 | | | | 39338082 | Diet and Oral Squamous Cell Carcinoma: A Scoping Review |
| Geniposide | 📋 | | | | 36382092 | Geniposide inhibits cell proliferation and migration in human oral squamous carcinoma cells via AMPK and JNK signaling pathways |
| Glutathione | 📋 | ✍ | ⛔ | | 32856877 | The Protective Effect of Antioxidants in Areca Nut Extract-Induced Oral Carcinogenesis |
| Grape | 📋 | | ⛔ | | 34283318 | Do grape and black mulberry molasses have an effect on oral mucositis and quality of life in patients with head and neck cancer? |
| Haritaki | 📋 | ✍ | ⛔ | | 39938761 | Investigating the Impact of Terminalia chebula, an underutilized functional fruit, on oral squamous cell carcinoma: Exploring Cell Death Mechanisms |
| HMB | 📋 | ✍ | ⛔ | | 37739730 | Efficacy of beta-hydroxy-beta-methylbutyrate, arginine, and glutamine for the prevention of mucositis induced by platinum-based chemoradiation in head and neck cancer: A phase II study |
| Honeysuckle | 📋 | | ⛔ | | 34617520 | Combination of plant phenolics and isoquinolinium alkaloids protects gingival fibroblast and improves post-extraction healing after lower third molar extraction |
| Horny Goat Weed | 📋 | ✍ | ⛔ | | 39686428 | Epimedium applied in the clinical treatment of osteoporosis patients with periodontitis |
| Hydroxytyrosol | 📋 | | | | 34610362 | Hydroxytyrosol prevents periodontitis-induced bone loss by regulating mitochondrial function and mitogen-activated protein kinase signaling of bone cells |
| Hypericin | 📋 | | | | 39861682 | Riboflavin- and Hypericin-Mediated Antimicrobial Photodynamic Therapy as Alternative Treatments for Oral Candidiasis: A Systematic Review |
| Irisin | 📋 | | | | 36863620 | Knockdown of SIRT3 perturbs protective effects of irisin against bone loss in diabetes and periodontitis |
| Isorhamnetin | 📋 | | | | 32654232 | Isorhamnetin induces the paraptotic cell death through ROS and the ERK/MAPK pathway in OSCC cells |
| Kudzu Root | 📋 | ✍ | ⛔ | | 29121799 | Pueraria lobate Inhibits RANKL-Mediated Osteoclastogenesis Via Downregulation of CREB/PGC1β/c-Fos/NFATc1 Signaling |
| L-Ornithine | 📋 | ✍ | ⛔ | | 34816043 | Effects of l-arginine and l-ornithine supplementations on the treatment of chronic periodontitis: A preliminary randomized short-term clinical trial |
| L-Threonine | 📋 | ✍ | ⛔ | | 35692238 | Clinical efficacy of hydroxyapatite toothpaste containing Polyol Germanium Complex (PGC) with threonine in the treatment of dentine hypersensitivity |
| L-Tryptophan | 📋 | ✍ | ⛔ | | 38958698 | The role of nutraceuticals in the management of temporomandibular disorders |
| Lemon Balm | 📋 | ✍ | ⛔ | | 30831467 | Homeopathic medicine of Melissa officinalis combined or not with Phytolacca decandra in the treatment of possible sleep bruxism in children: A crossover randomized triple-blinded controlled clinical trial |
| Lemon Balm Essential Oil | 📋 | ✍ | ⛔ | | 32041100 | Methylcellulose Hydrogel with Melissa officinalis Essential Oil as a Potential Treatment for Oral Candidiasis |
| Lemongrass | 📋 | ✍ | ⛔ | | 38399374 | Exploring the Clinical Applications of Lemongrass Essential Oil: A Scoping Review |
| Ligustilide | 📋 | | | | 35494068 | Z-Ligustilide Induces c-Myc-Dependent Apoptosis via Activation of ER-Stress Signaling in Hypoxic Oral Cancer Cells |
| Liquiritigenin | 📋 | | | | 34488535 | Liquiritigenin exerts the anti-cancer role in oral cancer via inducing autophagy-related apoptosis through PI3K/AKT/mTOR pathway inhibition in vitro and in vivo |
| Loquat | 📋 | ✍ | ⛔ | | 21473904 | Protective changes of inflammation-related gene expression by the leaves of Eriobotrya japonica in the LPS-stimulated human gingival fibroblast: microarray analysis |
| Lotus | 📋 | | ⛔ | | 31127738 | Anticariogenic activity of Nelumbo nucifera leaf extract in oral healthcare |
| Lutein | 📋 | ✍ | ⛔ | | 34072756 | Lutein Treatment Effects on the Redox Status and Metalloproteinase-9 (MMP-9) in Oral Cancer Squamous Cells-Are There Therapeutical Hopes? |
| Malva Sylvestris | 📋 | | ⛔ | | 32592827 | Antibiofilm and anti-caries effects of an experimental mouth rinse containing Matricaria chamomilla L. extract under microcosm biofilm on enamel |
| Malvidin | 📋 | | | | 28974439 | Blueberry and Malvidin Inhibit Cell Cycle Progression and Induce Mitochondrial-Mediated Apoptosis by Abrogating the JAK/STAT-3 Signalling Pathway |
| Manganese | 📋 | ✍ | ⛔ | | 36260219 | Manganese suppresses the development of oral leukoplakia by activating the immune response |
| Mango | 📋 | | ⛔ | | 38024868 | Effect of Mangifera Indica (Mango) on Dental Caries: A Systematic Review |
| Minerals | 📋 | | | | 39036231 | The Role and Significance of Trace Elements in Oral Submucosal Fibrosis |
| Morin | 📋 | | | | 40578119 | Anti-inflammatory, antioxidant, and antimicrobial evaluation of morin |
| Mushrooms | 📋 | | ⛔ | | 35440880 | Immunomodulatory Effect and an Intervention of TNF Signalling Leading to Apoptotic and Cell Cycle Arrest on ORL-204 Oral Cancer Cells by Tiger Milk Mushroom, Lignosus rhinocerus |
| Mustard | 📋 | | ⛔ | | 38791329 | Clinical Effect of Thioglycosides Extracted from White Mustard on Dental Plaque and Gingivitis: Randomized, Single-Blinded Clinical Trial |
| Myrtle Essential Oil | 📋 | ✍ | ⛔ | | 19306024 | The Efficacy of a Paste Containing Myrtus Communis (Myrtle) in the Management of Recurrent Aphthous Stomatitis: A Randomized Controlled Trial |
| Nattokinase | 📋 | ✍ | ⛔ | | 34717590 | Nattokinase crude extract enhances oral mucositis healing |
| Neem Oil | 📋 | ✍ | ⛔ | | 23066297 | Evaluation of anti-plaque microbial activity of Azadirachta indica (neem oil) in vitro: A pilot study |
| Neferine | 📋 | | | | 33156559 | Chemomodulatory effect of neferine on DMBA-induced squamous cell carcinogenesis: Biochemical and molecular approach |
| Nicotinamide | 📋 | ✍ | ⛔ | | 35341208 | Nicotinamide could reduce growth and cariogenic virulence of Streptococcus mutans |
| Nicotinamide Riboside | 📋 | ✍ | ⛔ | | 37952104 | Nicotinamide riboside modulates HIF-1 signaling to maintain and enhance odontoblastic differentiation in human dental pulp stem cells |
| Nitrate | 📋 | ✍ | ⛔ | | 38733290 | Effects of dietary nitrate supplementation on oral health and associated markers of systemic health: a systematic review |
| NMN | 📋 | ✍ | ⛔ | | 39633075 | Nicotinamide mononucleotide suppresses cellular senescence and increases aquaporin 5 expression in the submandibular gland of aged male mice to ameliorate aging-related dry mouth |
| Nootkatone | 📋 | | | | 39192685 | Nootkatone mitigates periodontal inflammation and reduces alveolar bone loss via Nrf2/HO-1 and NF-κB pathways in rat model of periodontitis |
| Nuciferine | 📋 | | | | 37833979 | Nuciferine Inhibits Oral Squamous Cell Carcinoma Partially through Suppressing the STAT3 Signaling Pathway |
| Okra | 📋 | | ⛔ | | 40016714 | In-vitro evaluation of the effect of okra (Abelmoschus esculentus L.) extract on periodontal cells: a comprehensive study of cellular and molecular impacts |
| Oleanolic Acid | 📋 | | | | 40208786 | Application of network pharmacology, bioinformatics, computational molecular docking, and experimental validation to study the anticancer effects of oleanolic acid in oral squamous carcinoma cells |
| Oleuropein | 📋 | | | | 40506561 | Oleuropein regulates ubiquitination-mediated Mcl-1 turnover and exhibits antitumor activity |
| Omega-6 Fatty Acids | 📋 | ✍ | ⛔ | | 34586209 | New tendencies in non-surgical periodontal therapy |
| Oregano | 📋 | ✍ | ⛔ | | 36406439 | Origanum vulgare ethanolic extracts as a promising source of compounds with antimicrobial, anti-biofilm, and anti-virulence activity against dental plaque bacteria |
| Osmanthus | 📋 | ✍ | ⛔ | | 25912528 | The ethanol extract of Osmanthus fragrans attenuates Porphyromonas gingivalis lipopolysaccharide-stimulated inflammatory effect through the nuclear factor erythroid 2-related factor-mediated antioxidant signalling pathway |
| Patchouli | 📋 | ✍ | ⛔ | | 14615795 | [Anti-Candida albicans activity of essential oils including Lemongrass (Cymbopogon citratus) oil and its component, citral] |
| Peppermint | 📋 | ✍ | ⛔ | | 27912953 | Evaluating the effect of Matricaria recutita and Mentha piperita herbal mouthwash on management of oral mucositis in patients undergoing hematopoietic stem cell transplantation: A randomized, double blind, placebo controlled clinical trial |
| Perilla | 📋 | ✍ | | | 37834377 | Therapeutic Effects of Perilla Phenols in Oral Squamous Cell Carcinoma |
| Phellodendron | 📋 | ✍ | ⛔ | | 38794173 | Evaluating the Effectiveness of Phellodendron Amurense Ruprecht Extract as a Natural Anti-Caries Material |
| Phloretin | 📋 | | | | 39186834 | Natural compound phloretin restores periodontal immune homeostasis via HIF-1α-regulated PI3K/Akt and glycolysis in macrophages |
| Phytoestrogens | 📋 | | ⛔ | | 36909165 | Overview on postmenopausal osteoporosis and periodontitis: The therapeutic potential of phytoestrogens against alveolar bone loss |
| PQQ | 📋 | ✍ | ⛔ | | 35173876 | Pyrroloquinoline quinone inhibits ligature-induced alveolar bone loss through regulation of redox balance and cell senescence |
| PUFA | 📋 | | | | 36839179 | Polyunsaturated Fatty Acids and Their Immunomodulatory Actions in Periodontal Disease |
| Quercitrin | 📋 | | | | 26558438 | Quercitrin for periodontal regeneration: effects on human gingival fibroblasts and mesenchymal stem cells |
| Rose | 📋 | | | | 40248632 | Exploring the potential of Rosa chinensis, Rosa cymosa, and Rosa indica in oral disease prevention: A multifaceted approach |
| Royal Jelly | 📋 | ✍ | ⛔ | | 34822003 | Comparative study of royal jelly, propolis, and photobiomodulation therapies in 5-fluorouracil-related oral mucositis in rats |
| Rutin | 📋 | ✍ | ⛔ | | 33801378 | The Antioxidant Effect of Curcumin and Rutin on Oxidative Stress Biomarkers in Experimentally Induced Periodontitis in Hyperglycemic Wistar Rats |
| Saffron | 📋 | ✍ | ⛔ | | 32102527 | Anti-Cancer Effects of Traditional Medicinal Herbs on Oral Squamous Cell Carcinoma |
| Safranal | 📋 | | | | 28718677 | Evaluation of the Cytotoxic Activity of Crocin and Safranal, Constituents of Saffron, in Oral Squamous Cell Carcinoma (KB Cell Line) |
| Sage Essential Oil | 📋 | | ⛔ | | 21894557 | [Anticancer activity of Salvia officinalis essential oil against HNSCC cell line (UMSCC1)] |
| Saw Palmetto | 📋 | ✍ | ⛔ | | 38740241 | Targeting SRD5A1 and MMP-2/NLRP3/TGF-β1 axis alleviates the amlodipine-induced gingival hyperplasia in rats: Emerging role of saw palmetto and folic acid |
| Scutellarin | 📋 | | | | 38494963 | [The mechanism of scutellarin inhibiting oral leukoplakia carcinogenesis based on network pharmacology and in vitro cytology] |
| Sea Buckthorn | 📋 | ✍ | ⛔ | | 30674068 | Benefits of sea buckthorn (Hippophae rhamnoides) pulp oil-based mouthwash on oral health |
| Seafood | 📋 | | | | 32770320 | Omega-3 polyunsaturated fatty acids: a promising approach for the management of oral lichen planus |
| Sesamin | 📋 | ✍ | | | 32397656 | Antimetastatic Effects of Sesamin on Human Head and Neck Squamous Cell Carcinoma through Regulation of Matrix Metalloproteinase-2 |
| Sesamol | 📋 | | | | 34586880 | Sesamol induces cytotoxicity via mitochondrial apoptosis in SCC-25 cells |
| Sirtuin Activators | 📋 | | | | 36060706 | Oxidative stress and inflammation regulation of sirtuins: New insights into common oral diseases |
| Soybean Oil | 📋 | | ⛔ | | 31508794 | Effect of avocado/soybean unsaponifiables on periodontal repair in rats with arthritis and induced periodontitis |
| Spearmint Essential Oil | 📋 | ✍ | ⛔ | | 19659716 | The effect of Mentha spicata and Eucalyptus camaldulensis essential oils on dental biofilm |
| St. Johns Wort Oil | 📋 | | ⛔ | | 36547112 | The Antimicrobial and Anti-Biofilm Effects of Hypericum perforatum Oil on Common Pathogens of Periodontitis: An In Vitro Study |
| Star Anise | 📋 | ✍ | ⛔ | | 34195261 | Crossover Analysis of the Astringent, Antimicrobial, and Anti-inflammatory Effects of Illicium verum/Star Anise in the Oral Cavity |
| Stevia | 📋 | ✍ | ⛔ | | 37563632 | Stevioside reduces inflammation in periodontitis by changing the oral bacterial composition and inhibiting P. gingivalis in mice |
| Strawberry | 📋 | ✍ | ⛔ | | 18211028 | Isolation and identification of strawberry phenolics with antioxidant and human cancer cell antiproliferative properties |
| Sunflower Oil | 📋 | ✍ | ⛔ | | 39926945 | Comparison and Evaluation of the Efficacy of Sesame Oil, Coconut Oil, and Sunflower Oil Pulling on Gingival Health-A Triple-Blind Randomized Clinical Trial |
| Tannic Acid | 📋 | ✍ | ⛔ | | 38398630 | Antibacterial Activity of Plant Polyphenols Belonging to the Tannins against Streptococcus mutans-Potential against Dental Caries |
| Taro Root | 📋 | | ⛔ | | 34684091 | Effects of Colocasia antiquorum var. Esculenta Extract In Vitro and In Vivo against Periodontal Disease |
| Telmisartan | 📋 | | ⛔ | | 35347812 | Effect of telmisartan on an experimental model of periodontitis in mice |
| Urolithins | 📋 | | | | 38788395 | Urolithin A, induces apoptosis and autophagy crosstalk in Oral Squamous Cell Carcinoma via mTOR /AKT/ERK1/2 pathway |
| Ursolic Acid | 📋 | ✍ | ⛔ | | 39489326 | Anti-cariogenic effect of experimental resin cement containing ursolic acid using dental microcosm biofilm |
| Vegetables | 📋 | | | | 39338082 | Diet and Oral Squamous Cell Carcinoma: A Scoping Review |
| Vitamin B3 | 📋 | ✍ | ⛔ | | 31583741 | Periodontitis and Intake of Thiamine, Riboflavin and Niacin Among Korean Adults |
| Vitamin K2 | 📋 | ✍ | ⛔ | | 37998429 | A Case Control Study Evaluating the Relationship between Vitamin K2 Serum Level and Periodontitis |
| Vitamin K2 mk-4 | 📋 | ✍ | | | 33517171 | Vitamin K2 promotes the osteogenic differentiation of periodontal ligament stem cells via the Wnt/β-catenin signaling pathway |
| Watercress | 📋 | ✍ | ⛔ | | 37057243 | Effect of Nasturtium Extract on Oral Cancer |
| White Tea | 📋 | | ⛔ | | 29242687 | The antiplaque efficacy of white tea extract mouthrinse |
| Wine | 📋 | | ⛔ | | 34534374 | Effect of red wine or its polyphenols on induced apical periodontitis in rats |
| Wormwood Essential Oil | 📋 | | ⛔ | | 28845008 | [Therapeutic effect of Artemisia argyi on oral ulcer in rats] |
| Yogurt | 📋 | | ⛔ | | 35066918 | Yogurt product intake and reduction of tooth loss risk in a Japanese community |
