| Substance |
Info | Dose |
Warn | Link |
PubMed |
Latest article |
| Curcumin | 📋 | ✍ | ⛔ | | 38634264 | Curcumin Effects on Age-Related Changes in Oral Immunity: An In Vivo Study |
| Bee Propolis | 📋 | ✍ | ⛔ | | 38710295 | Efficacy of Natural Products in Preventing Oral Mucositis Resulting from Cancer Therapies: A Network Meta-analysis of Randomized Controlled Trials |
| Aloe Vera | 📋 | ✍ | ⛔ | | 38595509 | Efficacy of Aloe Vera, Amlexanox (5%), and Triamcinolone Acetonide (0.1%) in the Management of Oral Lichen Planus |
| Vitamin D3 | 📋 | ✍ | ⛔ | | 38618072 | Association between vitamin D levels and risk of periodontitis in patients with metabolic syndrome |
| Resveratrol | 📋 | ✍ | ⛔ | | 38706943 | Resveratrol facilitates bone formation in high-glucose conditions |
| Melatonin | 📋 | ✍ | ⛔ | | 38540297 | Melatonin Decreases Alveolar Bone Loss in Rats with Experimental Periodontitis and Osteoporosis: A Morphometric and Histopathologic Study |
| Quercetin | 📋 | ✍ | ⛔ | | 38474862 | Quercetin in the Prevention of Induced Periodontal Disease in Animal Models: A Systematic Review and Meta-Analysis |
| EGCG | 📋 | ✍ | ⛔ | | 37867423 | Epigallocatechin gallate (EGCG) alleviates the inflammatory response and recovers oral microbiota in acetic acid-induced oral inflammation mice |
| Vitamin C | 📋 | ✍ | ⛔ | | 38245765 | Vitamin intake and periodontal disease: a meta-analysis of observational studies |
| Probiotics | 📋 | ✍ | ⛔ | | 38652926 | Comparative evaluation of the efficacy of probiotic, Aloe vera, povidine-iodine, and chlorhexidine mouthwashes in the treatment of gingival inflammation: A randomized controlled trial |
| Omega-3 Fatty Acids | 📋 | ✍ | ⛔ | | 38510979 | Nonsurgical Treatment of Periodontitis in Menopausal Patients: A Randomized Control Trial |
| Licorice Root | 📋 | ✍ | ⛔ | | 37958031 | The Power of Licorice ( Radix glycyrrhizae) to Improve Oral Health: A Comprehensive Review of Its Pharmacological Properties and Clinical Implications |
| Holy Basil | 📋 | ✍ | ⛔ | | 38523946 | Assessment of the Efficiency of Tulsi Extract as a Locally Administered Medication Agent and Its Comparison With Curcumin in the Treatment of Periodontal Pockets |
| Lycopene | 📋 | ✍ | ⛔ | | 38344076 | Systematic review and meta-analysis of the antioxidant capacity of lycopene in the treatment of periodontal disease |
| Grape Seed extract | 📋 | ✍ | ⛔ | | 37519954 | Evaluation of Remineralization Potential of Natural Substances on Artificially Induced Carious Lesions in Primary Teeth: An In Vitro Study |
| Cannabidiol | 📋 | ✍ | ⛔ | | 38649735 | Cannabidiol - an effective analgesic for toothache? |
| Chamomile | 📋 | ✍ | ⛔ | | 38710295 | Efficacy of Natural Products in Preventing Oral Mucositis Resulting from Cancer Therapies: A Network Meta-analysis of Randomized Controlled Trials |
| Green Tea | 📋 | ✍ | ⛔ | | 35706460 | Effect of Green Tea on the Level of Salivary Interleukin-1 Beta in Patients with Chronic Periodontitis: A Randomized Clinical Trial |
| Pomegranate Peel extract | 📋 | ✍ | ⛔ | | 38277034 | Pomegranate extract in polyphosphate-fluoride mouthwash reduces enamel demineralization |
| Green Tea Polyphenols | 📋 | ✍ | ⛔ | | 37916550 | Supplementation of Energy Drinks with Green Tea Extract: Effect on In Vitro Abrasive/Erosive Dentin Wear |
| Medicinal Plants | 📋 | | | | 38318501 | Plants with Anti-Ulcer Activity and Mechanism: A Review of Preclinical and Clinical Studies |
| Honey | 📋 | ✍ | ⛔ | | 38710295 | Efficacy of Natural Products in Preventing Oral Mucositis Resulting from Cancer Therapies: A Network Meta-analysis of Randomized Controlled Trials |
| Cinnamaldehyde | 📋 | | | | 37268049 | Cinnamaldehyde inhibits Enterococcus faecalis biofilm formation and promotes clearance of its colonization by modulation of phagocytes in vitro |
| Berberine | 📋 | ✍ | ⛔ | | 38729536 | Coptidis rhizoma extract alleviates oropharyngeal candidiasis by gC1qR-EGFR/ERK/c-fos axis-induced endocytosis of oral epithelial cells |
| Essential Oils | 📋 | | ⛔ | | 38310236 | Efficacy of flossing and mouth rinsing regimens on plaque and gingivitis: a randomized clinical trial |
| Metformin | 📋 | ✍ | ⛔ | | 38496895 | Metformin alleviates junctional epithelium senescence via the AMPK/SIRT1/autophagy pathway in periodontitis induced by hyperglycemia |
| Neem | 📋 | ✍ | | | 38585261 | The immunomodulatory impact of naturally derived neem leaf glycoprotein on the initiation progression model of 4NQO induced murine oral carcinogenesis: a preclinical study |
| Vitamin E | 📋 | ✍ | ⛔ | | 38650639 | Associations between single and multiple dietary vitamins and the risk of periodontitis: results from NHANES 2009-2014 |
| Micronutrients | 📋 | | ⛔ | | 38698274 | Multi-nutrients and periodontal disease - a new adjunct to improving treatment outcomes? A randomised placebo-control clinical trial |
| Tea Tree Essential Oil | 📋 | | ⛔ | | 35821403 | Effectiveness of tea tree oil versus chlorhexidine in the treatment of periodontal diseases: a systematic review |
| Cranberry | 📋 | ✍ | ⛔ | | 37375955 | The Protective Role of Cranberries and Blueberries in Oral Cancer |
| N-Acetyl Cysteine | 📋 | ✍ | ⛔ | | 37701655 | Efficacy of Oral Mucoadhesive N-Acetylcysteine Tablets in Treatment of Recurrent Aphthous Stomatitis: A Randomized Double-Blind, Placebo-Controlled Clinical Trial |
| Pomegranate | 📋 | | ⛔ | | 38169678 | Effect of hydroalcoholic extract of whole pomegranate fruit on cariogenic bacteria and its clinical effect on dental plaque formation in 8-10-year-old children |
| Astaxanthin | 📋 | ✍ | ⛔ | | 38524025 | Efficacy and Safety of Astaxanthin in the Management of Oral Submucous Fibrosis: A Preliminary Randomized Controlled Trial |
| Bromelain | 📋 | ✍ | ⛔ | | 38075000 | Bromelain regulates TRP channels to induce orofacial nociception relief in adult zebrafish |
| Cinnamon | 📋 | ✍ | ⛔ | | 34447078 | Cariostatic Efficacy of Cinnamon Water Extract on Streptococcus mutans: An In vitro Study |
| Ginsenosides | 📋 | ✍ | ⛔ | | 38530541 | Ginsenoside Rb1 Deters Cell Proliferation, Induces Apoptosis, Alleviates Oxidative Stress, and Antimetastasis in Oral Squamous Carcinoma Cells |
| Moringa Oleifera | 📋 | ✍ | ⛔ | | 37881795 | Moringa oleifera Use in Maintaining Oral Health and Its Potential Use in Regenerative Dentistry |
| Turmeric | 📋 | ✍ | ⛔ | | 38560351 | Efficacy of turmeric in the treatment of oral mucositis in patients with head and neck cancer after radiotherapy or chemoradiotherapy: a systematic review and meta-analysis |
| Zinc | 📋 | ✍ | ⛔ | | 36864527 | Prevention of radiotherapy-related oral mucositis with zinc and polyherbal mouthwash: a double-blind, randomized clinical trial |
| Baicalein | 📋 | ✍ | ⛔ | | 36843559 | Network pharmacology and bioinformatics analysis on the underlying mechanisms of baicalein against oral squamous cell carcinoma |
| Cinnamon Essential Oil | 📋 | ✍ | ⛔ | | 34572724 | Antibiofilm Potential of Medicinal Plants against Candida spp. Oral Biofilms: A Review |
| Hesperidin | 📋 | ✍ | ⛔ | | 38435153 | Hesperidin Inhibits Oral Cancer Cell Growth via Apoptosis and Inflammatory Signaling-Mediated Mechanisms: Evidence From In Vitro and In Silico Analyses |
| Hyaluronic Acid | 📋 | ✍ | ⛔ | | 37920632 | Hyaluronic Acid: Exploring Its Versatile Applications in Dentistry |
| Nigella Sativa | 📋 | ✍ | ⛔ | | 37975389 | The effect of Nigella sativa extracts against Porphyromonas gingivalis isolated from periodontitis patients |
| Baicalin | 📋 | ✍ | ⛔ | | 38380717 | Baicalin induces ferroptosis in oral squamous cell carcinoma by suppressing the activity of FTH1 |
| Coconut Oil | 📋 | | ⛔ | | 35178093 | Virgin Coconut Oil as a New Concept for Periodontal Tissue Regeneration via Expressions of TNF- α and TGF- β 1 |
| Eugenol | 📋 | | | | 38295310 | Clinical Impact of Root Canal Treatment Combined with Eugenol Cement on Acute Pulpitis and its Influence on Inflammatory Factor Levels |
| Licochalcones | 📋 | | | | 32632823 | Biocompatible combinations of nisin and licorice polyphenols exert synergistic bactericidal effects against Enterococcus faecalis and inhibit NF-κB activation in monocytes |
| Mangosteen | 📋 | ✍ | ⛔ | | 38034260 | Inhibition of Oral Fibrinogenesis Through Transforming Growth Factor-Beta/SMAD2/3 Signalling Inhibition Using Mangosteen Pericarp Extract |
| Sodium Bicarbonate | 📋 | ✍ | ⛔ | | 36597048 | Prevention and the treatment of oral mucositis: the efficacy of sodium bicarbonate vs other agents: a systematic review |
| Allicin | 📋 | ✍ | ⛔ | | 34502071 | Allicin May Promote Reversal of T-Cell Dysfunction in Periodontitis via the PD-1 Pathway |
| Andrographolide | 📋 | | | | 35624605 | Real-Time Monitoring the Cytotoxic Effect of Andrographolide on Human Oral Epidermoid Carcinoma Cells |
| Apigenin | 📋 | ✍ | ⛔ | | 37211399 | Combined effect of apigenin and reduced graphene oxide against Enterococcus faecalis biofilms |
| Black Tea | 📋 | ✍ | ⛔ | | 37273306 | Anticariogenic Activity of Black Tea: An In Vivo Study |
| Capsaicin | 📋 | ✍ | ⛔ | | 38699845 | Capsaicin attenuates Porphyromonas gingivalis-suppressed osteogenesis of periodontal ligament stem cells via regulating mitochondrial function and activating PI3K/AKT/mTOR pathway |
| Carvacrol | 📋 | ✍ | ⛔ | | 38605312 | The inhibitory effects of carvacrol, nystatin, and their combination on oral candidiasis isolates |
| Fucoidan | 📋 | ✍ | ⛔ | | 37648299 | Fucoidan Enhances Cisplatin-induced Effects on SCC-25 Human Oral Cancer Cells by Inhibiting the PI3K/AKT Pathway |
| L-Glutamine | 📋 | ✍ | ⛔ | | 38493953 | Clinical and biochemical assessment of the effect of glutamine in management of radiation induced oral mucositis in patients with head and neck cancer: Randomized controlled clinical trial |
| Luteolin | 📋 | ✍ | ⛔ | | 38304347 | Luteolin Is a Potential Immunomodulating Natural Compound against Pulpal Inflammation |
| Phytochemicals | 📋 | | | | 38611874 | Advances in Small Molecular Agents against Oral Cancer |
| Pine Bark | 📋 | ✍ | ⛔ | | 37162467 | Xerostomia and prevention of dryness with a Pycnogenol® mouth spray: a pilot study |
| Piperine | 📋 | ✍ | ⛔ | | 37762259 | Piperine Induces Apoptosis and Autophagy in HSC-3 Human Oral Cancer Cells by Regulating PI3K Signaling Pathway |
| Boric Acid | 📋 | ✍ | ⛔ | | 38692230 | Boric acid alleviates periodontal inflammation induced by IL-1β in human gingival fibroblasts |
| CoQ10 | 📋 | ✍ | ⛔ | | 37480004 | Clinical and biochemical assessment of the effect of topical use of coenzyme Q10 versus topical corticosteroid in management of symptomatic oral lichen planus: randomized controlled clinical trial |
| Crocin | 📋 | ✍ | ⛔ | | 36705490 | Osteogenic effect of crocin in human periodontal ligament stem cells via Wnt/β-catenin signaling |
| Ellagic Acid | 📋 | ✍ | ⛔ | | 34586188 | The effect of ellagic acid on the repair process of periodontal defects related to experimental periodontitis in rats |
| Fisetin | 📋 | ✍ | ⛔ | | 33928003 | Integrated analysis and identification of nine-gene signature associated to oral squamous cell carcinoma pathogenesis |
| Ginseng | 📋 | ✍ | ⛔ | | 38632037 | Panax notoginseng saponins improve oral submucous fibrosis by inhabiting the Wnt/β-catenin signal pathway |
| L-Arginine | 📋 | ✍ | ⛔ | | 38162235 | Arginine: A New Paradigm in Preventive Oral Care |
| Lipoic Acid | 📋 | ✍ | ⛔ | | 37021013 | The efficacy of alpha-lipoic acid in the management of burning mouth syndrome: An updated systematic review of randomized controlled clinical trials |
| Magnesium | 📋 | ✍ | ⛔ | | 37954114 | Nutrient insufficiencies and deficiencies involved in the pathogenesis of bruxism (Review) |
| Magnolol | 📋 | | | | 38132422 | Assessing the Antioxidant Benefits of Topical Carvacrol and Magnolol Periodontal Hydrogel Therapy in Periodontitis Associated with Diabetes in Wistar Rats |
| Milk Thistle | 📋 | ✍ | ⛔ | | 34968721 | Milk thistle (Silybum marianum (L.)Gaertn.): An overview about its pharmacology and medicinal uses with an emphasis on oral diseases |
| Naringenin | 📋 | ✍ | ⛔ | | 38154966 | Naringenin modulates GABA mediated response in a sexdependent manner in substantia gelatinosa neurons of trigeminal subnucleus caudalis in immature mice |
| Silibinin | 📋 | ✍ | | | 37476191 | Silibinin induces oral cancer cell apoptosis and reactive oxygen species generation by activating the JNK/c-Jun pathway |
| Thymoquinone | 📋 | | ⛔ | | 38485457 | Thymoquinone potentiates anti-cancer effects of cisplatin in oral squamous cell carcinoma via targeting oxidative stress |
| Xylitol | 📋 | ✍ | ⛔ | | 38430364 | The effect of xylitol chewing gums and candies on caries occurrence in children: a systematic review with special reference to caries level at study baseline |
| Acemannan | 📋 | | | | 28477996 | Stimulation of Dentin Regeneration by Using Acemannan in Teeth with Lipopolysaccharide-induced Pulp Inflammation |
| Aged Garlic | 📋 | ✍ | ⛔ | | 38026667 | Therapeutic effect of aged garlic extract on gingivitis in dogs |
| Frankincense | 📋 | ✍ | ⛔ | | 38666917 | Frankincense (Boswellia serrata) Extract Effects on Growth and Biofilm Formation of Porphyromonas gingivalis, and Its Intracellular Infection in Human Gingival Epithelial Cells |
| Ginger | 📋 | ✍ | ⛔ | | 34393401 | Effect of green tea, ginger plus green tea, and chlorhexidine mouthwash on plaque-induced gingivitis: A randomized clinical trial |
| Lactobacillus plantarum | 📋 | | ⛔ | | 38668014 | Effect of Probiotics Lactobacillus rhamnosus and Lactobacillus plantarum on Caries and Periodontal Diseases: A Systematic Review |
| Peppermint Essential Oil | 📋 | ✍ | ⛔ | | 36864527 | Prevention of radiotherapy-related oral mucositis with zinc and polyherbal mouthwash: a double-blind, randomized clinical trial |
| Roselle | 📋 | ✍ | ⛔ | | 38376437 | Antioxidant and Antineoplastic Activities of Hibiscus sabdariffa Linn. Petal Extracts against Oral Squamous Cell Carcinoma Cell Line |
| Theaflavins | 📋 | ✍ | | | 34698557 | Effect of Theaflavin on Oral Bacteria in Japanese Subjects: A Randomized, Placebo-Controlled, Double-Blind Study |
| Vitamin A | 📋 | ✍ | ⛔ | | 38245765 | Vitamin intake and periodontal disease: a meta-analysis of observational studies |
| Black Tea Polyphenols | 📋 | | | | 36008552 | Prevention of carcinogen-induced oral cancers by polymeric black tea polyphenols via modulation of EGFR-Akt-mTOR pathway |
| Blueberry | 📋 | ✍ | ⛔ | | 37375955 | The Protective Role of Cranberries and Blueberries in Oral Cancer |
| CAPE | 📋 | | | | 37289416 | Effects of caffeic acid phenethyl ester against multi-species cariogenic biofilms |
| Garlic | 📋 | ✍ | ⛔ | | 33437712 | Clinical Quantitative Antibacterial Potency of Garlic-Lemon Against Sodium Hypochlorite in Infected Root Canals: A Double-blinded, Randomized, Controlled Clinical Trial |
| Glycyrrhizic Acid | 📋 | ✍ | ⛔ | | 34953035 | Glycyrrhizin regulates rat TMJOA progression by inhibiting the HMGB1-RAGE/TLR4-NF-κB/AKT pathway |
| Gotu Kola | 📋 | ✍ | ⛔ | | 37247290 | Evaluation of the Anti-Carcinogenic Effect of Centella Asiatica on Oral Cancer Cell Line: In vitro Study |
| Lemongrass Essential Oil | 📋 | ✍ | ⛔ | | 37534506 | Comparative Evaluation of 0.25% Lemongrass Oil Mouthwash and 0.2% Chlorhexidine Mouthwash in Fixed Orthodontic Patients Suffering from Gingivitis |
| Marigold | 📋 | ✍ | ⛔ | | 29368902 | [Action of Calendula officinalis essence on bone preservation after the extraction] |
| Mulberry | 📋 | | ⛔ | | 38225885 | Comparison of the effectiveness of Morus alba and chlorhexidine gels as an adjunct to scaling and root planing on stage II periodontitis - A randomized controlled clinical trial |
| Nobiletin | 📋 | ✍ | | | 34335088 | Nobiletin Decreases Inflammatory Mediator Expression in Tumor Necrosis Factor-Stimulated Human Periodontal Ligament Cells |
| Olive Oil | 📋 | ✍ | ⛔ | | 37629298 | Oil Pulling and Polyphenols: Treatment of Gingivitis Patients with 'Itri Extra-Virgin Olive Oil' |
| Peony | 📋 | | ⛔ | | 37601076 | Efficacy and safety of total glucosides of paeony in the treatment of recurrent aphthous ulcers: a single-center, double-blind, randomized, placebo-controlled clinical trial |
| Prebiotics | 📋 | ✍ | ⛔ | | 38559858 | Effect of Prebiotics Supplements on Salivary pH and Salivary Buffer Capacity in Children with Early Childhood Caries: An In Vivo Study |
| Reishi Mushrooms | 📋 | ✍ | ⛔ | | 37180834 | Aqueous-soluble components of sporoderm-removed Ganoderma lucidum spore powder promote ferroptosis in oral squamous cell carcinoma |
| Skullcap | 📋 | ✍ | ⛔ | | 36549214 | Efficacy identification and active compounds screening of topically administration of Scutellaria Radix in oral ulcer |
| Artemisinin | 📋 | | | | 37699886 | Artemisinins inhibit oral candidiasis caused by Candida albicans through the repression on its hyphal development |
| Beta-Cryptoxanthin | 📋 | | | | 37049698 | Anti-Inflammatory Effects of β-Cryptoxanthin on 5-Fluorouracil-Induced Cytokine Expression in Human Oral Mucosal Keratinocytes |
| Carnosic Acid | 📋 | | | | 35722077 | Carnosic Acid as an intracanal medicament performs better than triple antibiotic paste and calcium hydroxide to eradicate Enterococcus faecalis from root canal: An in vitro confocal laser scanning microscopic study |
| Clove | 📋 | | ⛔ | | 33866666 | A randomized clinical study to examine the oral hygiene efficacy of a novel herbal toothpaste with zinc over a 6 month period |
| Clove Essential Oil | 📋 | | ⛔ | | 34633113 | In vitro inhibition of a multispecies oral cavity biofilm by Syzygium aromaticum essential oil |
| Dihydroquercetin | 📋 | | | | 36134855 | Effect of taxifolin on methotrexate-induced oxidative and inflammatory oral mucositis in rats: biochemical and histopathological evaluation |
| Diosgenin | 📋 | | | | 38458369 | Potential targets of diosgenin for the treatment of oral squamous cell carcinoma and their bioinformatics and transcriptional profiling analyses |
| Echinacea | 📋 | ✍ | ⛔ | | 36605140 | Evaluation of the efficacy of Echinacea on clinical indices of Erosive Oral Lichen Planus: A randomized double-blind clinical trial |
| Eicosapentaenoic Acid | 📋 | ✍ | ⛔ | | 36749095 | Effect of local administration of eicosapentaenoic acid on the jaw-opening reflex in rats |
| Eucalyptus | 📋 | ✍ | ⛔ | | 36865731 | Comparative Evaluation of Antimicrobial Efficacy of Sodium Hypochlorite, Triphala, Eucalyptus, and Carvacrol against Enterococcus faecalis: An In Vitro study |
| Gallic Acid | 📋 | | ⛔ | | 37957813 | Gallic acid induces osteoblast differentiation and alleviates inflammatory response through GPR35/GSK3β/β-catenin signaling pathway in human periodontal ligament cells |
| Ginger extract | 📋 | ✍ | ⛔ | | 35384365 | Effects of ginger (Zingiber officinale) on gingival fibroblasts: An in vitro study |
| Goji Berry | 📋 | ✍ | ⛔ | | 37119863 | Lycium barbarum polysaccharide-glycoprotein ameliorates ionizing radiation-induced epithelial injury by regulating oxidative stress and ferroptosis via the Nrf2 pathway |
| Graviola | 📋 | ✍ | ⛔ | | 38075540 | In vitro Evaluation of Cytotoxic Effects of Methanolic Leaf Extracts of Annona muricata on Oral Squamous Cell Carcinoma-15 Cell Lines and its Effect On Expression of Bcl 2-associated X protein, B-cell C/Lymphoma 2 and p53 Genes |
| Indian Gooseberry | 📋 | | ⛔ | | 37529983 | Phyllanthus emblica fruits: a polyphenol-rich fruit with potential benefits for oral management |
| Iodine | 📋 | ✍ | ⛔ | | 38305374 | Clinical Efficacy of Different Concentrations of Povidone Iodine in the Management of Peri-Implant Mucositis |
| Lavender Essential Oil | 📋 | ✍ | ⛔ | | 36629536 | Antinociceptive and anxiolytic-like effects of Lavandula angustifolia essential oil on rat models of orofacial pain |
| Mangiferin | 📋 | | ⛔ | | 35762316 | Mangiferin promotes the osteogenic differentiation of human periodontal ligament stem cells via TGF‑β/SMAD2 signaling |
| Polyphenols | 📋 | | | | 35011503 | Propolis and Diet Rich in Polyphenols as Cariostatic Agents Reducing Accumulation of Dental Plaque |
| Pterostilbene | 📋 | ✍ | ⛔ | | 35340874 | Pterostilbene attenuates the proliferation and differentiation of TNF-α-treated human periodontal ligament stem cells |
| Sage | 📋 | ✍ | ⛔ | | 31952199 | Anti-Bacterial and Anti-Inflammatory Effects of Toothpaste with Swiss Medicinal Herbs towards Patients Suffering from Gingivitis and Initial Stage of Periodontitis: from Clinical Efficacy to Mechanisms |
| Sesame Oil | 📋 | | ⛔ | | 34824517 | Novel Treatment Approach of Oral Submucous Fibrosis in a 6-year-old Girl: A Case Report |
| Withaferin A | 📋 | | | | 33202766 | Low Dose Combined Treatment with Ultraviolet-C and Withaferin a Enhances Selective Killing of Oral Cancer Cells |
| Aloe-Emodin | 📋 | | | | 36302645 | Effects of aloe-emodin on alveolar bone in Porphyromonas gingivalis-induced periodontitis rat model: a pilot study |
| Antioxidants | 📋 | | ⛔ | | 38323465 | Associations of dietary antioxidant intake with periodontal health among US adults: An exploratory mediation analysis via mitochondrial function |
| Apple | 📋 | | ⛔ | | 29970630 | Effect of crude apple extract on the cariogenic factors of Streptococcus mutans: An in vitro study |
| Arjuna | 📋 | ✍ | ⛔ | | 37814683 | Antimicrobial and anti-inflammatory activity of Terminalia arjuna |
| Astragalosides | 📋 | ✍ | ⛔ | | 37454920 | Astragaloside reduces toxic effect of periodontal ligament fibroblasts induced by lipopolysaccharide |
| Avocado | 📋 | ✍ | ⛔ | | 31508794 | Effect of avocado/soybean unsaponifiables on periodontal repair in rats with arthritis and induced periodontitis |
| Beta-Carotene | 📋 | ✍ | ⛔ | | 26423734 | Higher Intakes of Fruits and Vegetables, β-Carotene, Vitamin C, α-Tocopherol, EPA, and DHA Are Positively Associated with Periodontal Healing after Nonsurgical Periodontal Therapy in Nonsmokers but Not in Smokers |
| Calcium | 📋 | ✍ | ⛔ | | 36618706 | Dietary vitamin D and calcium and periodontitis: A population-based study |
| Catechins | 📋 | | | | 35660639 | Green tea catechins inhibit Porphyromonas gulae LPS-induced inflammatory responses in human gingival epithelial cells: Running title |
| Cherry | 📋 | | ⛔ | | 33497417 | Effects of a tart cherry (Prunus cerasus L.) phenolic extract on Porphyromonas gingivalis and its ability to impair the oral epithelial barrier |
| Chlorogenic Acid | 📋 | ✍ | ⛔ | | 36742612 | Cytotoxic Role of Chlorogenic Acid on Oral Squamous Cell Carcinoma Cell Line |
| Chrysin | 📋 | ✍ | ⛔ | | 36555388 | Chrysin Induces Apoptosis via the MAPK Pathway and Regulates ERK/mTOR-Mediated Autophagy in MC-3 Cells |
| Citral | 📋 | | | | 37244090 | Orofacial anti-hypernociceptive effect of citral in acute and persistent inflammatory models in rats |
| Cocoa | 📋 | ✍ | ⛔ | | 37764711 | Biological Properties and Antimicrobial Potential of Cocoa and Its Effects on Systemic and Oral Health |
| Coptis Chinensis | 📋 | | ⛔ | | 38729536 | Coptidis rhizoma extract alleviates oropharyngeal candidiasis by gC1qR-EGFR/ERK/c-fos axis-induced endocytosis of oral epithelial cells |
| Dioscin | 📋 | | | | 38385066 | Dioscin Alleviates Periodontitis by Inhibiting NLRP3 Inflammasome Activation via Regulation of K+ Homeostasis and Mitochondrial Function |
| Fiber | 📋 | ✍ | ⛔ | | 37764817 | Role of Dietary Fibre in Managing Periodontal Diseases-A Systematic Review and Meta-Analysis of Human Intervention Studies |
| Genistein | 📋 | ✍ | ⛔ | | 36058937 | Genistein anticancer efficacy during induced oral squamous cell carcinoma: an experimental study |
| Gingerol | 📋 | ✍ | | | 34697150 | [6]-Gingerol Suppresses Oral Cancer Cell Growth by Inducing the Activation of AMPK and Suppressing the AKT/mTOR Signaling Pathway |
| Glucosamine | 📋 | ✍ | ⛔ | | 36902359 | Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review |
| Guava | 📋 | | ⛔ | | 35906612 | The effect of hydroalcoholic extract of Psidium guajava L. on experimentally induced oral mucosal wound in rat |
| Hesperetin | 📋 | | | | 30663412 | Modulating effect of hesperetin on the molecular expression pattern of apoptotic and cell proliferative markers in 7,12-dimethylbenz(a)anthracene-induced oral carcinogenesis |
| Honokiol | 📋 | | | | 33980461 | Honokiol inhibits arecoline-induced oral fibrogenesis through transforming growth factor-β/Smad2/3 signaling inhibition |
| Icariin | 📋 | ✍ | | | 38144358 | Icariin negatively regulated lipopolysaccharide-induced inflammation and ameliorated the odontogenic activity of human dental pulp cells in vitro |
| Kaempferol | 📋 | ✍ | ⛔ | | 38223666 | Kaempferol induces apoptosis through the MAPK pathway and regulates JNK-mediated autophagy in MC-3 cells |
| Lemon Essential Oil | 📋 | ✍ | ⛔ | | 35080078 | The Effect of Lemon Essential Oil on Halitosis |
| Mango Leaf | 📋 | | ⛔ | | 28611324 | Comparative evaluation of Mangifera indica leaf mouthwash with chlorhexidine on plaque accumulation, gingival inflammation, and salivary streptococcal growth |
| Mastic | 📋 | ✍ | ⛔ | | 37865987 | Sialagogic Effects Through Olfactory Stimulation with Mastic Resin and α-pinene Volatiles in vivo |
| Myrrh | 📋 | ✍ | ⛔ | | 36714089 | Effect of an herbal mouthwash on periodontal indices in patients with plaque-induced gingivitis: A cross-over clinical trial |
| Myrtle | 📋 | ✍ | ⛔ | | 33224129 | Phytocompounds vs. Dental Plaque Bacteria: In vitro Effects of Myrtle and Pomegranate Polyphenolic Extracts Against Single-Species and Multispecies Oral Biofilms |
| Nutmeg | 📋 | ✍ | ⛔ | | 35959299 | Comparative evaluation of nutmeg mouthwash and 0.2% chlorhexidine gluconate mouthwash on halitosis and plaque control: A randomized clinical trial |
| Oregano Essential Oil | 📋 | ✍ | ⛔ | | 35094612 | Physicochemical characteristics and antimicrobial activity of Origanum vulgare L. essential oil and carvacrol on cariogenic bacteria: an in vitro and in silico study |
| Paeonol | 📋 | | | | 37025919 | Efficacy of a toothpaste containing paeonol, potassium nitrate, and strontium chloride on dentine hypersensitivity: A double-blind randomized controlled trial in Chinese adults |
| Papain | 📋 | ✍ | ⛔ | | 34194848 | BRIX3000® Papain Gel for Cavity Treatment in the Adult Patient |
| Piperlongumine | 📋 | | | | 38452870 | Anti-cancer agent piperlongumine is an inhibitor of transient receptor potential melastatin 7 channel in oral squamous cell carcinoma |
| Polydatin | 📋 | ✍ | | | 36678905 | Chemopreventive and Anticancer Role of Resveratrol against Oral Squamous Cell Carcinoma |
| Postbiotics | 📋 | | | | 38402294 | How probiotics, prebiotics, synbiotics, and postbiotics prevent dental caries: an oral microbiota perspective |
| Puerarin | 📋 | ✍ | ⛔ | | 36718661 | Puerarin Suppresses Glycolysis and Increases Cisplatin Chemosensitivity in Oral Squamous Cell Carcinoma via FBXW7/mTOR Signaling |
| Punicalagin | 📋 | ✍ | ⛔ | | 32854243 | Evaluation of the In Vitro Oral Wound Healing Effects of Pomegranate ( Punica granatum) Rind Extract and Punicalagin, in Combination with Zn (II) |
| Rapamycin | 📋 | ✍ | | | 38276004 | Rapamycin as a Potential Alternative Drug for Squamous Cell Gingiva Carcinoma (Ca9-22): A Focus on Cell Cycle, Apoptosis and Autophagy Genetic Profile |
| Raspberry | 📋 | ✍ | ⛔ | | 33435253 | Chemical Composition, Antioxidant and Antimicrobial Activity of Raspberry, Blackberry and Raspberry-Blackberry Hybrid Leaf Buds |
| Shogaol | 📋 | | | | 38481719 | Prophylactic and therapeutic effects of (6)-shogaol on alveolar bone loss in experimental periodontitis |
| Silymarin | 📋 | ✍ | ⛔ | | 38356030 | Antifibrotic effect of silymarin on arecoline-induced fibrosis in primary human buccal fibroblasts: an in silico and in vitro analysis |
| Spirulina | 📋 | ✍ | ⛔ | | 36550811 | Antioxidant effect of spirulina in chronic periodontitis |
| St. Johns Wort | 📋 | ✍ | ⛔ | | 33964648 | Evaluation of the chemopreventive effects of Hypericum perforatum L on DMBA-applied rat oral mucosa |
| Sulforaphane | 📋 | ✍ | ⛔ | | 27339168 | Prevention of Carcinogen-Induced Oral Cancer by Sulforaphane |
| Tanshinone | 📋 | | | | 37670974 | Tanshinone IIA inhibits cell viability and promotes PUMA-mediated apoptosis of oral squamous cell carcinoma |
| Thyme | 📋 | ✍ | ⛔ | | 36760146 | EFFECTS OF THYME ON HALITOSIS IN GINGIVITIS PATIENTS Can Thyme Mouthwash Prevent Halitosis - a Randomized Trial? |
| Thyme Essential Oil | 📋 | | ⛔ | | 33625248 | Antibiofilm effects of Thymus vulgaris and Hyptis spicigera essential oils on cariogenic bacteria |
| Thymol | 📋 | ✍ | ⛔ | | 34867378 | In Vitro and In Vivo Anti-infective Potential of Thymol Against Early Childhood Caries Causing Dual Species Candida albicans and Streptococcus mutans |
| Toothache Plant | 📋 | | | | 37671677 | The potential of Acmella oleracea as a nutraceutical source for the symptomatic treatment of Burning Mouth Syndrome |
| Vitamin B Complex | 📋 | | ⛔ | | 38245765 | Vitamin intake and periodontal disease: a meta-analysis of observational studies |
| Vitamins | 📋 | | | | 37888131 | The Role of Vitamins in Oral Potentially Malignant Disorders and Oral Cancer: A Systematic Review |
| Acacetin | 📋 | | | | 32797769 | Protective effect of acacetin in human periodontal ligament cells via regulation of autophagy and inflammation |
| Anethole | 📋 | | | | 37242484 | Synergistic Effect of Anethole and Platinum Drug Cisplatin against Oral Cancer Cell Growth and Migration by Inhibiting MAPKase, Beta-Catenin, and NF-κB Pathways |
| Anthocyanins | 📋 | ✍ | ⛔ | | 25658905 | Anthocyanins From Black Rice (Oryza Sativa L.) Demonstrate Antimetastatic Properties by Reducing MMPs and NF-κB Expressions in Human Oral Cancer CAL 27 Cells |
| Apple Polyphenols | 📋 | | ⛔ | | 35281303 | Thinned-Young Apple Polyphenols Inhibit Halitosis-Related Bacteria Through Damage to the Cell Membrane |
| Arctigenin | 📋 | | | | 30884781 | Arctigenin Reduces Myofibroblast Activities in Oral Submucous Fibrosis by LINC00974 Inhibition |
| Arnica | 📋 | ✍ | ⛔ | | 31952199 | Anti-Bacterial and Anti-Inflammatory Effects of Toothpaste with Swiss Medicinal Herbs towards Patients Suffering from Gingivitis and Initial Stage of Periodontitis: from Clinical Efficacy to Mechanisms |
| Asiatic Acid | 📋 | | | | 37333763 | The Role of Asiatic Acid in Preventing Dental Pulp Inflammation: An in-vivo Study |
| Asiaticoside | 📋 | | | | 29520784 | Asiaticoside induces osteogenic differentiation of human periodontal ligament cells through the Wnt pathway |
| Balloon Flower | 📋 | ✍ | ⛔ | | 31137477 | In Vitro Effect of the Traditional Medicine Hainosan (Painongsan) on Porphyromonas gingivalis |
| Barberry | 📋 | ✍ | ⛔ | | 37315644 | Buccal spray of standardized Berberis aristata extract causes tumour regression, chemoprotection and downregulation of inflammatory mediators in oral cancer hamster model |
| Beets | 📋 | ✍ | ⛔ | | 34195102 | A Single Dose of Nitrate Increases Resilience Against Acidification Derived From Sugar Fermentation by the Oral Microbiome |
| Bergamot | 📋 | ✍ | ⛔ | | 37748407 | Bergapten exerts a chondroprotective effect in temporomandibular joint osteoarthritis by combining intestinal flora alteration and reactive oxygen species reduction |
| Beta-Glucan | 📋 | ✍ | ⛔ | | 37525561 | Metastasis and immunosuppression promoted by mtDNA and PD-L1 in extracellular vesicles are reversed by WGP β-glucan in oral squamous cell carcinoma |
| Beta-Lapachone | 📋 | | | | 30071298 | β-Lapachone and its iodine derivatives cause cell cycle arrest at G 2/M phase and reactive oxygen species-mediated apoptosis in human oral squamous cell carcinoma cells |
| Betaine | 📋 | ✍ | ⛔ | | 37072503 | Randomized clinical trial on the clinical effects of a toothpaste containing extra virgin olive oil, xylitol, and betaine in gingivitis |
| Bilberry | 📋 | ✍ | ⛔ | | 34439567 | Bilberry ( Vaccinium myrtillus L.) Powder Has Anticarcinogenic Effects on Oral Carcinoma In Vitro and In Vivo |
| Bitter Melon | 📋 | ✍ | ⛔ | | 35267362 | Microwave- and Ultrasound-Assisted Extraction of Cucurbitane-Type Triterpenoids from Momordica charantia L. Cultivars and Their Antiproliferative Effect on SAS Human Oral Cancer Cells |
| Bitter Orange | 📋 | ✍ | ⛔ | | 31137477 | In Vitro Effect of the Traditional Medicine Hainosan (Painongsan) on Porphyromonas gingivalis |
| Boswellic Acid | 📋 | ✍ | ⛔ | | 38513840 | Acetyl-11-keto-beta-boswellic acid inhibits cell proliferation and growth of oral squamous cell carcinoma via RAB7B-mediated autophagy |
| Butyrate | 📋 | | ⛔ | | 37775917 | Butyrate Inhibits Dendritic Cell Activation and Alleviates Periodontitis |
| Caffeine | 📋 | ✍ | ⛔ | | 35892784 | Effect of Coffee on Lipopolysaccharide-Induced Immortalized Human Oral Keratinocytes |
| Cat's Claw | 📋 | ✍ | ⛔ | | 27119588 | Antimicrobial activity and substantivity of Uncaria tomentosa in infected root canal dentin |
| Chokeberry | 📋 | ✍ | ⛔ | | 34846271 | Can the chokeberry juice be used as additional therapy for burning mouth syndrome in menopausal women? |
| Chondroitin | 📋 | ✍ | ⛔ | | 35588467 | Efficacy of the use of chondroitin sulphate and glucosamine for the treatment of temporomandibular joint dysfunction: A systematic review and meta-analysis |
| Coffee | 📋 | ✍ | ⛔ | | 38333482 | A Comparative Analysis of Three Antioxidants in Addition to Scaling and Root Planing in Stage Three Grade B Periodontitis |
| Cordycepin | 📋 | | | | 38023774 | Cordycepin Induces Apoptosis through JNK-Mediated Caspase Activation in Human OEC-M1 Oral Cancer Cells |
| Coriander Essential Oil | 📋 | ✍ | ⛔ | | 24901768 | Coriandrum sativum L. (Coriander) essential oil: antifungal activity and mode of action on Candida spp., and molecular targets affected in human whole-genome expression |
| D-Limonene | 📋 | ✍ | ⛔ | | 35026511 | Limonene, a citrus monoterpene, non-complexed and complexed with hydroxypropyl-β-cyclodextrin attenuates acute and chronic orofacial nociception in rodents: Evidence for involvement of the PKA and PKC pathway |
| Daidzein | 📋 | ✍ | ⛔ | | 34942044 | Daidzein promotes the proliferation and osteogenic differentiation of periodontal ligament stem cell |
| Diosmin | 📋 | ✍ | ⛔ | | 27544550 | Diosmin induce apoptosis through modulation of STAT-3 signaling in 7,12 dimethylbenz(a)anthracene induced harmster buccal pouch carcinogenesis |
| Docosahexaenoic Acid | 📋 | ✍ | ⛔ | | 34699926 | Identification of docosahexaenoic and eicosapentaenoic acids multiple targets facing periodontopathogens |
| Elderberry | 📋 | ✍ | ⛔ | | 35866676 | The Effect of Mouthwash with Sambucus williamsii var. coreana Extract on Halitosis: A Randomised, Double-Blind, Placebo-Controlled Study |
| Eucommia | 📋 | ✍ | ⛔ | | 35932002 | Effect of Eucommia water extract on gingivitis and periodontitis in experimental rats |
| Fig | 📋 | | ⛔ | | 29657427 | Antibacterial activity of fig leaf ( Ficus carica Linn.) extract against Enterococcus faecalis and its cytotoxicity effects on fibroblast cells |
| Food | 📋 | | | | 34778347 | Beverages Consumption and Oral Health in the Aging Population: A Systematic Review |
| Fucoxanthin | 📋 | ✍ | ⛔ | | 34393435 | Fucoxanthin induced apoptotic cell death in oral squamous carcinoma (KB) cells |
| Gardenia | 📋 | | ⛔ | | 34674717 | Huanglianjiedu Decoction as an effective treatment for oral squamous cell carcinoma based on network pharmacology and experimental validation |
| Ginkgolic Acid | 📋 | | | | 31970286 | Ginkgolic Acid, a SUMO-1 Inhibitor, Inhibits the Progression of Oral Squamous Cell Carcinoma by Alleviating SUMOylation of SMAD4 |
| Glabridin | 📋 | | | | 32632823 | Biocompatible combinations of nisin and licorice polyphenols exert synergistic bactericidal effects against Enterococcus faecalis and inhibit NF-κB activation in monocytes |
| Horsetail Grass | 📋 | ✍ | ⛔ | | 36794024 | Equisetum arvense Inhibits Alveolar Bone Destruction in a Rat Model with Lipopolysaccharide (LPS)-Induced Periodontitis |
| Iron | 📋 | ✍ | ⛔ | | 37408351 | Iron level participates in the pathological damages of dental caries in infant rats by affecting enamel mineralization |
| Isoliquiritigenin | 📋 | | | | 37930332 | Isoliquiritigenin Inhibits Oral Squamous Cell Carcinoma and Overcomes Chemoresistance by Destruction of Survivin |
| Kiwifruit | 📋 | ✍ | ⛔ | | 29520772 | The effect of twice daily kiwifruit consumption on periodontal and systemic conditions before and after treatment: A randomized clinical trial |
| Knotweed | 📋 | ✍ | ⛔ | | 30720102 | Autophagy and apoptotic machinery caused by Polygonum cuspidatum extract in cisplatin‑resistant human oral cancer CAR cells |
| Lemon | 📋 | | ⛔ | | 33512251 | Effect of Honey-Lemon Spray Versus Benzydamine Hydrochloride Spray on Radiation-Induced Acute Oral Mucositis in Head and Neck Cancer Patients: A Pilot, Randomized, Double-Blind, Active-Controlled Clinical Trial |
| Lime | 📋 | | ⛔ | | 34204096 | Evaluation of Mouthwash Containing Citrus hystrix DC., Moringa oleifera Lam. and Azadirachta indica A. Juss. Leaf Extracts on Dental Plaque and Gingivitis |
| Linalool | 📋 | | ⛔ | | 38096923 | Analgesic effect of linalool odor on oral ulcerative mucositis-induced pain in rats |
| Lingonberry | 📋 | | ⛔ | | 34835994 | Lingonberries-General and Oral Effects on the Microbiome and Inflammation |
| Magnolia | 📋 | ✍ | ⛔ | | 33889369 | The antibacterial effect of Magnolia mouthwash on the levels of salivary Streptococcus mutans in dental plaque: a randomized, single-blind, placebo-controlled trial |
| MSM | 📋 | ✍ | ⛔ | | 34671266 | Methylsulfonylmethane Increases the Alveolar Bone Density of Mandibles in Aging Female Mice |
| Myricetin | 📋 | | ⛔ | | 33971542 | Discovery of myricetin as an inhibitor against Streptococcus mutans and an anti-adhesion approach to biofilm formation |
| Naringin | 📋 | ✍ | ⛔ | | 18444138 | Inhibition of oral carcinogenesis by citrus flavonoids |
| Nimbolide | 📋 | | | | 38561609 | The Neem Limonoid Nimbolide Modulates Key Components of the DNA Damage Response Signalling in Cellular and Animal Models of Oral Squamous Cell Carcinoma |
| Noni | 📋 | | ⛔ | | 38004017 | Effect of Plant-Based Mouthwash ( Morinda citrifolia and Ocimum sanctum) on TNF-α, IL-α, IL-β, IL-2, and IL-6 in Gingival Crevicular Fluid and Plaque Scores of Patients Undergoing Fixed Orthodontic Treatment |
| Oak Bark | 📋 | ✍ | ⛔ | | 33895758 | Microbiological aspects of conservative treatment of periodontal disease using gel-based preparations |
| Ollive Leaf extract | 📋 | ✍ | ⛔ | | 27942549 | Topical Olive Leaf Extract Improves Healing of Oral Mucositis in Golden Hamsters |
| Oolong Tea | 📋 | | ⛔ | | 35873431 | Oolong Tea Consumption and the Risk of Oral Squamous Cell Carcinoma: A Propensity Score-Based Analysis in Southeast China |
| Paeoniflorin | 📋 | | | | 37340760 | Anti-inflammatory and pro-regenerative effects of a monoterpene glycoside on experimental periodontitis in a rat model of diabetes |
| Papaya | 📋 | ✍ | ⛔ | | 37283020 | Anticancer Effects of Carica papaya L. and Benzyl Isothiocyanate on an Oral Squamous Cell Carcinoma Cell Line: An In Vitro Study |
| Proanthocyanidins | 📋 | | | | 36167610 | Efficacy of Proanthocyanidins in Nonsurgical Periodontal Therapy |
| Procyanidins | 📋 | | ⛔ | | 35566283 | Procyanidins and Their Therapeutic Potential against Oral Diseases |
| Rosemary | 📋 | ✍ | ⛔ | | 26850813 | Evaluation of the efficacy of a polyherbal mouthwash containing Zingiber officinale, Rosmarinus officinalis and Calendula officinalis extracts in patients with gingivitis: A randomized double-blind placebo-controlled trial |
| Rosemary Essential Oil | 📋 | ✍ | ⛔ | | 34365060 | Advantages of using toothpaste containing propolis and plant oils for gingivitis prevention and oral cavity hygiene in cleft lip/palate patients |
| Rosmarinic Acid | 📋 | ✍ | | | 32521932 | Anticancer Effects of Rosmarinic Acid in Human Oral Cancer Cells Is Mediated via Endoplasmic Reticulum Stress, Apoptosis, G2/M Cell Cycle Arrest and Inhibition of Cell Migration |
| Salvianolic Acid | 📋 | | | | 31831723 | Salvianolic Acid C Attenuates LPS-Induced Inflammation and Apoptosis in Human Periodontal Ligament Stem Cells via Toll-Like Receptors 4 (TLR4)/Nuclear Factor kappa B (NF-κB) Pathway |
| Selenium | 📋 | ✍ | ⛔ | | 36110830 | Assessment of Utility of Lycopene, Selenium, and Vitamin E in Management of Oral Leukoplakia |
| Tangeretin | 📋 | | | | 38022093 | Tangeretin's Anti-apoptotic Signaling Mechanisms in Oral Cancer Cells: In Vitro Anti-cancer Activity |
| Tea | 📋 | | | | 34504542 | Camellia sinensis in Dentistry: Technological Prospection and Scientific Evidence |
| Tea Polyphenols | 📋 | | | | 30640129 | Tea polyphenols protect gingival keratinocytes against TNF-α-induced tight junction barrier dysfunction and attenuate the inflammatory response of monocytes/macrophages |
| Theobromine | 📋 | ✍ | ⛔ | | 38302447 | The antimicrobial activity of theobromine against cariogenic microbes: an in vitro pilot study |
| Vitamin B12 | 📋 | ✍ | ⛔ | | 33103958 | Role of vitamin B12 in treating recurrent aphthous stomatitis: A review |
| Vitamin B2 | 📋 | ✍ | ⛔ | | 36625571 | Riboflavin Targets the Cellular Metabolic and Ribosomal Pathways of Candida albicans In Vitro and Exhibits Efficacy against Oropharyngeal Candidiasis |
| Vitamin K | 📋 | ✍ | ⛔ | | 37198606 | Association of vitamin K, fibre intake and progression of periodontal attachment loss in American adults |
| Acai Berry | 📋 | ✍ | ⛔ | | 36290625 | Açaí ( Euterpe oleracea Mart.) Attenuates Oxidative Stress and Alveolar Bone Damage in Experimental Periodontitis in Rats |
| Alpha-Linolenic Acid | 📋 | ✍ | ⛔ | | 38068849 | Protective Effect of Alpha-Linolenic Acid on Human Oral Squamous Cell Carcinoma Metastasis and Apoptotic Cell Death |
| Amygdalin | 📋 | ✍ | ⛔ | | 31110425 | Effect of Amygdalin on Oral Cancer Cell Line: An in vitro Study |
| Angelica | 📋 | ✍ | ⛔ | | 35682836 | Butylidenephthalide Abrogates the Snail-Induced Cancer Stemness in Oral Carcinomas |
| Apricot Kernels | 📋 | ✍ | ⛔ | | 31110425 | Effect of Amygdalin on Oral Cancer Cell Line: An in vitro Study |
| Ashwagandha | 📋 | ✍ | ⛔ | | 38303989 | In vitro cytotoxicity of Withania somnifera (L.) roots and fruits on oral squamous cell carcinoma cell lines: a study supported by flow cytometry, spectral, and computational investigations |
| Aspirin | 📋 | | ⛔ | | 37787044 | Adjunctive use of omega-3 fatty acids in combination with low-dose aspirin in periodontitis: Systematic review and meta-analysis |
| Bacopa Monnieri | 📋 | ✍ | ⛔ | | 37951147 | Anticancer activity of Bacopa monnieri through apoptosis induction and mitophagy-dependent NLRP3 inflammasome inhibition in oral squamous cell carcinoma |
| Basil | 📋 | ✍ | ⛔ | | 31942110 | Antifungal activity of solvent extracts of Piper betle and Ocimum sanctum Linn on Candida albicans: An in vitro comparative study |
| Basil Essential Oil | 📋 | ✍ | ⛔ | | 29207708 | In Vitro Anti-Cariogenic Plaque Effects of Essential Oils Extracted from Culinary Herbs |
| Bee Venom | 📋 | ✍ | ⛔ | | 35624686 | Apitherapy and Periodontal Disease: Insights into In Vitro, In Vivo, and Clinical Studies |
| Berries | 📋 | | | | 33466319 | Effect of a Berry Polyphenolic Fraction on Biofilm Formation, Adherence Properties and Gene Expression of Streptococcus mutans and Its Biocompatibility with Oral Epithelial Cells |
| Beta-Sitosterol | 📋 | ✍ | ⛔ | | 38107042 | Unlocking the potential of beta sitosterol: Augmenting the suppression of oral cancer cells through extrinsic and intrinsic signalling mechanisms |
| Betulinic Acid | 📋 | | | | 35538811 | Betulinic acid exerts anti-inflammatory activity in human periodontal ligament cells stimulated with lipopolysaccharide and/or high glucose |
| Blackberry | 📋 | | ⛔ | | 33435253 | Chemical Composition, Antioxidant and Antimicrobial Activity of Raspberry, Blackberry and Raspberry-Blackberry Hybrid Leaf Buds |
| Blackcurrant | 📋 | ✍ | ⛔ | | 22985050 | Anti-viral and anti-bacterial activities of an extract of blackcurrants (Ribes nigrum L.) |
| Burdock | 📋 | | ⛔ | | 28781531 | Antibacterial and Antifungal Activity of Endodontic Intracanal Medications |
| Calcium D-Glucarate | 📋 | ✍ | ⛔ | | 20393005 | Calcium glucarate inhibits DMBA-induced oral carcinogenesis in the hamster: histomorphometric evaluation |
| Capsanthin | 📋 | | | | 36141454 | The Utility of Capsicum annuum L. in Internal Medicine and In Dentistry: A Comprehensive Review |
| Cardamom | 📋 | ✍ | ⛔ | | 31430531 | Antibacterial and anti-inflammatory activities of cardamom (Elettaria cardamomum) extracts: Potential therapeutic benefits for periodontal infections |
| Cardamonin | 📋 | | | | 38281189 | Cardamonin decreases inflammatory mediator expression in IL-1β-stimulated human periodontal ligament cells |
| Chaga Mushrooms | 📋 | ✍ | ⛔ | | 38720012 | Chaga mushroom extract suppresses oral cancer cell growth via inhibition of energy metabolism |
| Chamomile Essential Oil | 📋 | ✍ | ⛔ | | 30820080 | A relative assessment of essential oil of Chrysopogon zizanioides and Matricaria chamomilla along with calcium hydroxide and chlorhexidine gel against Enterococcus faecalis in ex vivo root canal models |
| Chili Pepper | 📋 | | ⛔ | | 35600864 | The Antifibrotic and the Anticarcinogenic Activity of Capsaicin in Hot Chili Pepper in Relation to Oral Submucous Fibrosis |
| Chitosan | 📋 | ✍ | ⛔ | | 35214037 | General Characteristics, Biomedical and Dental Application, and Usage of Chitosan in the Treatment of Temporomandibular Joint Disorders: A Narrative Review |
| Chrysanthemum | 📋 | ✍ | ⛔ | | 36777434 | Effect of ethanol extract from Chrysanthemum cinerariifolium leaves on Ki-67 proliferation and dysplasia severity in a rat model of oral squamous cell carcinoma |
| Citrus Fruits | 📋 | | ⛔ | | 29753688 | Citrus fruits intake and oral cancer risk: A systematic review and meta-analysis |
| Clary Sage Essential Oil | 📋 | ✍ | ⛔ | | 28093319 | Anti-inflammatory effect of the Salvia sclarea L. ethanolic extract on lipopolysaccharide-induced periodontitis in rats |
| Coconut | 📋 | | ⛔ | | 35546458 | Comparative efficacy of topical coconut cream and clobetasol propionate ointment for the management of oral lichen planus: A double-blinded randomized control trial |
| Collagen | 📋 | ✍ | | | 36364735 | Impact of a Specific Collagen Peptide Food Supplement on Periodontal Inflammation in Aftercare Patients-A Randomised Controlled Trial |
| Copper | 📋 | ✍ | ⛔ | | 36185249 | A pro-oxidant combination of resveratrol and copper down-regulates hallmarks of cancer and immune checkpoints in patients with advanced oral cancer: Results of an exploratory study (RESCU 004) |
| Cordyceps | 📋 | ✍ | ⛔ | | 36072973 | Network Pharmacology and Molecular Docking Analysis Explores the Mechanisms of Cordyceps s inensis in the Treatment of Oral Lichen Planus |
| Coriander | 📋 | | ⛔ | | 31747377 | Vietnamese coriander inhibits cell proliferation, survival and migration via suppression of Akt/mTOR pathway in oral squamous cell carcinoma |
| Crocetin | 📋 | | | | 33133459 | Central H 2 histaminergic and alpha-2 adrenergic receptors involvement in crocetin-induced antinociception in orofacial formalin pain in rats |
| Cryptotanshinone | 📋 | | | | 36704921 | Cryptotanshinone inhibits oral squamous cell carcinoma through the autophagic pathway |
| D-Mannose | 📋 | ✍ | ⛔ | | 36031720 | D-Mannose alleviated alveolar bone loss in experimental periodontitis mice via regulating the anti-inflammatory effect of amino acids |
| Dairy | 📋 | | | | 37650016 | Influence of dairy products consumption on oral cancer risk: A meta-analysis |
| Date | 📋 | | ⛔ | | 35233390 | Cytotoxic and Antioxidant Effects of Phoenix dactylifera L. (Ajwa Date Extract) on Oral Squamous Cell Carcinoma Cell Line |
| Dihydroartemisinin | 📋 | | | | 34847839 | Dihydroartemisinin represses oral squamous cell carcinoma progression through downregulating mitochondrial calcium uniporter |
| Emodin | 📋 | | ⛔ | | 20659264 | Apoptotic effect of Polygonum Cuspidatum in oral cancer cells through the regulation of specificity protein 1 |
| Escin | 📋 | ✍ | ⛔ | | 22895831 | Escin inhibits lipopolysaccharide-induced inflammation in human periodontal ligament cells |
| Eucalyptus Essential Oil | 📋 | | ⛔ | | 38389967 | Efficacy of a Eucalyptus oil-based dentifrice in reducing plaque and gingival bleeding scores - A randomized clinical crossover study |
| Evening Primrose Oil | 📋 | ✍ | ⛔ | | 15898373 | Evening primrose oil effects on osteoclasts during tooth movement |
| Fish Collagen | 📋 | ✍ | ⛔ | | 35934799 | Marine collagen peptides: A novel biomaterial for the healing of oral mucosal ulcers |
| Fish Oil | 📋 | ✍ | ⛔ | | 22809098 | Combination of Astaxanthin and Fish Oil Supplementation Alters Antioxidant Enzyme Profile of Dental Pulp Tissue |
| Flavonoids | 📋 | | ⛔ | | 35331090 | Efficacy of Flavonoids in Combating Fluconazole Resistant Oral Candidiasis |
| Flaxseed | 📋 | ✍ | ⛔ | | 32924561 | Effect of a Homemade Salivary Substitute Prepared Using Chamomile ( Matricaria chamomilla L.) Flower and Flax ( Linum usitatissimum L.) Seed to Relieve Primary Burning Mouth Syndrome: A Preliminary Report |
| Flaxseed Oil | 📋 | ✍ | ⛔ | | 35485674 | Clinical Assessment of Efficacy of Omega 3 in Oral Submucous Fibrosis Patients - A Randomized Controlled Trial |
| Folate | 📋 | ✍ | ⛔ | | 30558282 | Serum Nutrient Levels and Aging Effects on Periodontitis |
| Frankincense Essential Oil | 📋 | | ⛔ | | 35807419 | Effects of Frankincense Compounds on Infection, Inflammation, and Oral Health |
| Genipin | 📋 | | | | 37792550 | Apoptotic activity of genipin in human oral squamous cell carcinoma in vitro by regulating STAT3 signaling |
| Geniposide | 📋 | | | | 36382092 | Geniposide inhibits cell proliferation and migration in human oral squamous carcinoma cells via AMPK and JNK signaling pathways |
| Ginkgolides | 📋 | | | | 34944919 | Ginkgolide B Regulates CDDP Chemoresistance in Oral Cancer via the Platelet-Activating Factor Receptor Pathway |
| Glutathione | 📋 | ✍ | ⛔ | | 32856877 | The Protective Effect of Antioxidants in Areca Nut Extract-Induced Oral Carcinogenesis |
| Grape | 📋 | | ⛔ | | 34283318 | Do grape and black mulberry molasses have an effect on oral mucositis and quality of life in patients with head and neck cancer? |
| Grapefruit extract | 📋 | ✍ | ⛔ | | 32759635 | Effect of Flavonoid Supplementation on Alveolar Bone Healing-A Randomized Pilot Trial |
| HMB | 📋 | ✍ | ⛔ | | 37739730 | Efficacy of beta-hydroxy-beta-methylbutyrate, arginine, and glutamine for the prevention of mucositis induced by platinum-based chemoradiation in head and neck cancer: A phase II study |
| Honeysuckle | 📋 | | ⛔ | | 34617520 | Combination of plant phenolics and isoquinolinium alkaloids protects gingival fibroblast and improves post-extraction healing after lower third molar extraction |
| Hydroxytyrosol | 📋 | | | | 34610362 | Hydroxytyrosol prevents periodontitis-induced bone loss by regulating mitochondrial function and mitogen-activated protein kinase signaling of bone cells |
| Irisin | 📋 | | | | 36863620 | Knockdown of SIRT3 perturbs protective effects of irisin against bone loss in diabetes and periodontitis |
| Isorhamnetin | 📋 | | | | 32654232 | Isorhamnetin induces the paraptotic cell death through ROS and the ERK/MAPK pathway in OSCC cells |
| Kudzu Root | 📋 | ✍ | ⛔ | | 29121799 | Pueraria lobate Inhibits RANKL-Mediated Osteoclastogenesis Via Downregulation of CREB/PGC1β/c-Fos/NFATc1 Signaling |
| L-Carnosine | 📋 | ✍ | ⛔ | | 32614361 | The Efficacy of a Dietary Supplement With Carnosine and Hibiscus Sabdariffa L. (AqualiefTM) in Patients With Xerostomia: A Randomized, Placebo-Controlled, Double-Blind Trial |
| L-Ornithine | 📋 | ✍ | ⛔ | | 34816043 | Effects of l-arginine and l-ornithine supplementations on the treatment of chronic periodontitis: A preliminary randomized short-term clinical trial |
| L-Threonine | 📋 | ✍ | ⛔ | | 35692238 | Clinical efficacy of hydroxyapatite toothpaste containing Polyol Germanium Complex (PGC) with threonine in the treatment of dentine hypersensitivity |
| Lemon Balm | 📋 | ✍ | ⛔ | | 30831467 | Homeopathic medicine of Melissa officinalis combined or not with Phytolacca decandra in the treatment of possible sleep bruxism in children: A crossover randomized triple-blinded controlled clinical trial |
| Lemon Balm Essential Oil | 📋 | ✍ | ⛔ | | 32041100 | Methylcellulose Hydrogel with Melissa officinalis Essential Oil as a Potential Treatment for Oral Candidiasis |
| Lemongrass | 📋 | ✍ | ⛔ | | 38399374 | Exploring the Clinical Applications of Lemongrass Essential Oil: A Scoping Review |
| Ligustilide | 📋 | | | | 35494068 | Z-Ligustilide Induces c-Myc-Dependent Apoptosis via Activation of ER-Stress Signaling in Hypoxic Oral Cancer Cells |
| Liquiritigenin | 📋 | | | | 34488535 | Liquiritigenin exerts the anti-cancer role in oral cancer via inducing autophagy-related apoptosis through PI3K/AKT/mTOR pathway inhibition in vitro and in vivo |
| Loquat | 📋 | ✍ | ⛔ | | 21473904 | Protective changes of inflammation-related gene expression by the leaves of Eriobotrya japonica in the LPS-stimulated human gingival fibroblast: microarray analysis |
| Lotus | 📋 | | ⛔ | | 31127738 | Anticariogenic activity of Nelumbo nucifera leaf extract in oral healthcare |
| Lutein | 📋 | ✍ | ⛔ | | 34072756 | Lutein Treatment Effects on the Redox Status and Metalloproteinase-9 (MMP-9) in Oral Cancer Squamous Cells-Are There Therapeutical Hopes? |
| Malva Sylvestris | 📋 | | ⛔ | | 32592827 | Antibiofilm and anti-caries effects of an experimental mouth rinse containing Matricaria chamomilla L. extract under microcosm biofilm on enamel |
| Malvidin | 📋 | | | | 28974439 | Blueberry and Malvidin Inhibit Cell Cycle Progression and Induce Mitochondrial-Mediated Apoptosis by Abrogating the JAK/STAT-3 Signalling Pathway |
| Manganese | 📋 | ✍ | ⛔ | | 36260219 | Manganese suppresses the development of oral leukoplakia by activating the immune response |
| Mango | 📋 | | ⛔ | | 38024868 | Effect of Mangifera Indica (Mango) on Dental Caries: A Systematic Review |
| Matcha Tea | 📋 | | | | 27867678 | Reduced Dental Plaque Formation in Dogs Drinking a Solution Containing Natural Antimicrobial Herbal Enzymes and Organic Matcha Green Tea |
| Mushrooms | 📋 | | ⛔ | | 35440880 | Immunomodulatory Effect and an Intervention of TNF Signalling Leading to Apoptotic and Cell Cycle Arrest on ORL-204 Oral Cancer Cells by Tiger Milk Mushroom, Lignosus rhinocerus |
| Myrtle Essential Oil | 📋 | ✍ | ⛔ | | 19306024 | The Efficacy of a Paste Containing Myrtus Communis (Myrtle) in the Management of Recurrent Aphthous Stomatitis: A Randomized Controlled Trial |
| Nattokinase | 📋 | ✍ | ⛔ | | 34717590 | Nattokinase crude extract enhances oral mucositis healing |
| Neem Oil | 📋 | ✍ | ⛔ | | 23066297 | Evaluation of anti-plaque microbial activity of Azadirachta indica (neem oil) in vitro: A pilot study |
| Neferine | 📋 | | | | 33156559 | Chemomodulatory effect of neferine on DMBA-induced squamous cell carcinogenesis: Biochemical and molecular approach |
| Nicotinamide | 📋 | ✍ | ⛔ | | 35341208 | Nicotinamide could reduce growth and cariogenic virulence of Streptococcus mutans |
| Nicotinamide Riboside | 📋 | ✍ | ⛔ | | 37952104 | Nicotinamide riboside modulates HIF-1 signaling to maintain and enhance odontoblastic differentiation in human dental pulp stem cells |
| Nitrate | 📋 | ✍ | ⛔ | | 38733290 | Effects of dietary nitrate supplementation on oral health and associated markers of systemic health: a systematic review |
| Nuciferine | 📋 | | | | 37833979 | Nuciferine Inhibits Oral Squamous Cell Carcinoma Partially through Suppressing the STAT3 Signaling Pathway |
| Omega-6 Fatty Acids | 📋 | ✍ | ⛔ | | 34586209 | New tendencies in non-surgical periodontal therapy |
| Oregano | 📋 | ✍ | ⛔ | | 36406439 | Origanum vulgare ethanolic extracts as a promising source of compounds with antimicrobial, anti-biofilm, and anti-virulence activity against dental plaque bacteria |
| Osmanthus | 📋 | ✍ | ⛔ | | 25912528 | The ethanol extract of Osmanthus fragrans attenuates Porphyromonas gingivalis lipopolysaccharide-stimulated inflammatory effect through the nuclear factor erythroid 2-related factor-mediated antioxidant signalling pathway |
| Patchouli | 📋 | ✍ | ⛔ | | 14615795 | [Anti-Candida albicans activity of essential oils including Lemongrass (Cymbopogon citratus) oil and its component, citral] |
| Peppermint | 📋 | ✍ | ⛔ | | 27912953 | Evaluating the effect of Matricaria recutita and Mentha piperita herbal mouthwash on management of oral mucositis in patients undergoing hematopoietic stem cell transplantation: A randomized, double blind, placebo controlled clinical trial |
| Perilla | 📋 | ✍ | | | 37834377 | Therapeutic Effects of Perilla Phenols in Oral Squamous Cell Carcinoma |
| Phytoestrogens | 📋 | | ⛔ | | 36909165 | Overview on postmenopausal osteoporosis and periodontitis: The therapeutic potential of phytoestrogens against alveolar bone loss |
| PQQ | 📋 | ✍ | ⛔ | | 35173876 | Pyrroloquinoline quinone inhibits ligature-induced alveolar bone loss through regulation of redox balance and cell senescence |
| PUFA | 📋 | | | | 36839179 | Polyunsaturated Fatty Acids and Their Immunomodulatory Actions in Periodontal Disease |
| Quercitrin | 📋 | | | | 26558438 | Quercitrin for periodontal regeneration: effects on human gingival fibroblasts and mesenchymal stem cells |
| Royal Jelly | 📋 | ✍ | ⛔ | | 34822003 | Comparative study of royal jelly, propolis, and photobiomodulation therapies in 5-fluorouracil-related oral mucositis in rats |
| Rutin | 📋 | ✍ | ⛔ | | 33801378 | The Antioxidant Effect of Curcumin and Rutin on Oxidative Stress Biomarkers in Experimentally Induced Periodontitis in Hyperglycemic Wistar Rats |
| Saffron | 📋 | ✍ | ⛔ | | 32102527 | Anti-Cancer Effects of Traditional Medicinal Herbs on Oral Squamous Cell Carcinoma |
| Safranal | 📋 | | | | 28718677 | Evaluation of the Cytotoxic Activity of Crocin and Safranal, Constituents of Saffron, in Oral Squamous Cell Carcinoma (KB Cell Line) |
| Sage Essential Oil | 📋 | | ⛔ | | 21894557 | [Anticancer activity of Salvia officinalis essential oil against HNSCC cell line (UMSCC1)] |
| Scutellarin | 📋 | | | | 38494963 | [The mechanism of scutellarin inhibiting oral leukoplakia carcinogenesis based on network pharmacology and in vitro cytology] |
| Sea Buckthorn | 📋 | ✍ | ⛔ | | 30674068 | Benefits of sea buckthorn (Hippophae rhamnoides) pulp oil-based mouthwash on oral health |
| Seafood | 📋 | | | | 32770320 | Omega-3 polyunsaturated fatty acids: a promising approach for the management of oral lichen planus |
| Sesamin | 📋 | ✍ | | | 32397656 | Antimetastatic Effects of Sesamin on Human Head and Neck Squamous Cell Carcinoma through Regulation of Matrix Metalloproteinase-2 |
| Sesamol | 📋 | | | | 34586880 | Sesamol induces cytotoxicity via mitochondrial apoptosis in SCC-25 cells |
| Sirtuin Activators | 📋 | | | | 36060706 | Oxidative stress and inflammation regulation of sirtuins: New insights into common oral diseases |
| Soy Isoflavones | 📋 | ✍ | ⛔ | | 35212419 | Soy isoflavones alleviate periodontal destruction in ovariectomized rats |
| Soybean Oil | 📋 | | ⛔ | | 31508794 | Effect of avocado/soybean unsaponifiables on periodontal repair in rats with arthritis and induced periodontitis |
| Spearmint Essential Oil | 📋 | ✍ | ⛔ | | 19659716 | The effect of Mentha spicata and Eucalyptus camaldulensis essential oils on dental biofilm |
| Spermidine | 📋 | | | | 37741450 | Spermidine Suppresses Oral Carcinogenesis through Autophagy Induction, DNA Damage Repair, and Oxidative Stress Reduction |
| St. Johns Wort Oil | 📋 | | ⛔ | | 36547112 | The Antimicrobial and Anti-Biofilm Effects of Hypericum perforatum Oil on Common Pathogens of Periodontitis: An In Vitro Study |
| Star Anise | 📋 | ✍ | ⛔ | | 34195261 | Crossover Analysis of the Astringent, Antimicrobial, and Anti-inflammatory Effects of Illicium verum/Star Anise in the Oral Cavity |
| Stevia | 📋 | ✍ | ⛔ | | 37563632 | Stevioside reduces inflammation in periodontitis by changing the oral bacterial composition and inhibiting P. gingivalis in mice |
| Strawberry | 📋 | ✍ | ⛔ | | 18211028 | Isolation and identification of strawberry phenolics with antioxidant and human cancer cell antiproliferative properties |
| Tannic Acid | 📋 | ✍ | ⛔ | | 38398630 | Antibacterial Activity of Plant Polyphenols Belonging to the Tannins against Streptococcus mutans-Potential against Dental Caries |
| Taro Root | 📋 | | ⛔ | | 34684091 | Effects of Colocasia antiquorum var. Esculenta Extract In Vitro and In Vivo against Periodontal Disease |
| Telmisartan | 📋 | | ⛔ | | 35347812 | Effect of telmisartan on an experimental model of periodontitis in mice |
| Tribulus Terrestris | 📋 | ✍ | ⛔ | | 33751830 | Tribulus terrestris fruit extract inhibits autophagic flux to diminish cell proliferation and metastatic characteristics of oral cancer cells |
| Vitamin B3 | 📋 | ✍ | ⛔ | | 31583741 | Periodontitis and Intake of Thiamine, Riboflavin and Niacin Among Korean Adults |
| Vitamin B6 | 📋 | ✍ | ⛔ | | 38650639 | Associations between single and multiple dietary vitamins and the risk of periodontitis: results from NHANES 2009-2014 |
| Vitamin K2 | 📋 | ✍ | ⛔ | | 37998429 | A Case Control Study Evaluating the Relationship between Vitamin K2 Serum Level and Periodontitis |
| Vitamin K2 mk-4 | 📋 | ✍ | | | 33517171 | Vitamin K2 promotes the osteogenic differentiation of periodontal ligament stem cells via the Wnt/β-catenin signaling pathway |
| Watercress | 📋 | ✍ | ⛔ | | 37057243 | Effect of Nasturtium Extract on Oral Cancer |
| White Tea | 📋 | | ⛔ | | 29242687 | The antiplaque efficacy of white tea extract mouthrinse |
| Wine | 📋 | | ⛔ | | 34534374 | Effect of red wine or its polyphenols on induced apical periodontitis in rats |
| Wormwood | 📋 | ✍ | ⛔ | | 23011328 | [Artemisia absinthium L. in complex treatment of inflammatory periodontal disease] |
| Wormwood Essential Oil | 📋 | | ⛔ | | 28845008 | [Therapeutic effect of Artemisia argyi on oral ulcer in rats] |
| Yogurt | 📋 | | ⛔ | | 35066918 | Yogurt product intake and reduction of tooth loss risk in a Japanese community |
| Yohimbine | 📋 | ✍ | | | 35970968 | Anticancer potential of yohimbine in drug-resistant oral cancer KB-ChR-8-5 cells |
